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Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
2014
Yu, E.A., Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong, Republic of Korea | Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Park, E.K., (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, Republic of Korea | Yoo, C.Y., Department of Computer Information, Gyeongnam Provincial Namhae College, Namhae, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20§¡/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4 ¡¿MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
Mostrar más [+] Menos [-]Antibacterial efficacy and safety of copper sulfate pentahydrate to cultured fish
1997
Heo, G.J. (Chungbuk National University, Chongju (Korea Republic). College of Veterinary Medicine)
Prevalence of Streptococci in arthritic piglets and healthy sows with reference to antibiotic resistance of isolates
1989
Cho, H.J. (National Animal Breeding Inst., Sungwhan (Korea R.)) | Yeo, S.G. (Kyongsang National Univ., Chinju (Korea R.). Coll. of Veterinary Medicine)
In order to establish the extent of Streptococcal arthritis piglets, isolation of Streptococci from arthritic lesions of 34 piglets were undertaken from November 1987 to October 1988 in Korea. Also determined were isolation frequency of Streptococci in nasal cavity of 250 healthy sows and antibiotic susceptibilities of the isolates. Streptococci were isolated from 52.9 % of 34 arthritic piglets and 20 strains isolated belonged to 4 S suis type I, 8 S suis type II, 2 Lancefield group C and 6 group E. From 28.8 % of 250 healthy sows, 72 strains of Streptococci were isolated and these consisted of 9 S suis type I, 51 S suis type II and 12 group C. Streptococcal arthritis seemed to occur prominently in piglets aged 2 to 4 weeks and in male than female. No significant difference were recognized in tarsal and carpal joints as affecting site. All of 92 isolates were sensitive to ampicillin and penicillin, and all strains of S suis type I and group E Streptococcus were also sensitive to chloramphenicol and cephalothin. To cephalothin all strains of group C Streptococcus were sensitive. The 1.7 to 100 % of 92 isolates were resistant with different prevalence to colistin, erythromycin, kanamycin, tetracycline, gentamycin, chloramphenicol and cephalothin. The 92.5 % of these resistant Streptococci were multiply drug-resistant strains. The drug resistant patterns most frequently encountered were Tc Cl Em Km Gm (16.3 %) in quintuple pattern, Tc Cl Em Km (16.3 %) in quadruple pattern, Tc Cl Em (10.9 %) in triple pattern and Cl Em (14.1 %) in double pattern
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