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Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
1999
Takada, A. (Hokkaido Univ., Sapporo (Japan)) | Okazaki, K. | Kida, H.
Intranasal administration of plasmid DNA encoding glycoprotein B of pseudorabies virus into mice induced both serum and secretory antibody responses. These mice resisted intranasal challenge with lethal dose of the virus, but did not intraperitoneal challenge. On the other hand, intramuscular injection of the plasmid induced less secretory and higher serum antibody responses than those of intranasally vaccinated mice. None of them was protected from virus challenge. The present results suggest that administration of plasmid DNA encoding glycoprotein B by respiratory mucosal route generates local secretory antibodies which serve to protect animals from pseudorabies virus infection
Mostrar más [+] Menos [-]The epidemiology of rabies in Zimbabwe. 1. Rabies in dogs (Canis familiaris)
1999
Bingham, J. | Foggin, C.M. (Central Veterinary Laboratory, Harare (Zimbabwe)) | Wandeler, A.I. | Hill, F.W.G.
Seroprevalence of infectious bursal disease in non-vaccinated indigenous and exotic chickens on selected farms around Gaborone, Botswana
1999
Mushi, E.Z. (Botswana College of Agriculture, Gaborone (Botswana)) | Binta, M.G. | Chabo, R.G. | Ndebele, R.T.
