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Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes
2008
Cloete, M.(Onderstepoort Veterinary Institute) | Dungu, B.(Onderstepoort Veterinary Institute ,Onderstepoort Biological Products) | Van Staden, L.I.(Onderstepoort Veterinary Institute) | Ismail-Cassim, N.(Onderstepoort Veterinary Institute) | Vosloo, W.(Onderstepoort Veterinary Institute)
Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that is primarily controlled by vaccination of susceptible animals and movement restrictions for animals and animal-derived products in South Africa. Vaccination using aluminium hydroxide gel-saponin (AS) adjuvanted vaccines containing the South African Territories (SAT) serotypes has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone and in controlling outbreaks in the free zone. Various vaccine formulations containing antigens derived from the SAT serotypes were tested in cattle that were challenged 1 year later. Both the AS and ISA 206B vaccines adjuvanted with saponin protected cattle against virulent virus challenge. The oil-based ISA 206B-adjuvanted vaccine with and without stimulators was evaluated in a field trial and both elicited antibody responses that lasted for 1 year. Furthermore, the ISA 206 adjuvanted FMD vaccine protected groups of cattle against homologous virus challenge at very low payloads, while pigs vaccinated with an emergency ISA 206B-based FMD vaccine containing the SAT 1 vaccine strains were protected against the heterologous SAT 1 outbreak strain.
Mostrar más [+] Menos [-]Isolation of serovar C-3 Haemophilus paragallinarum from Zimbabwe: A further indication of the need for the production of vaccines against infectious coryza containing local isolates of H. paragallinarum
2002
Bragg, R.R. (Free State Univ., Bloemfontein (South Africa). Microbiology and Biochemistry Dept.)
Alternative cell lines for the propagation of lumpy skin disease virus
2001
Binepal, Y.S. | Ongadi, F.A. | Chepkwony, J.C. (Kenya Agricultural Research Inst., Nairobi (Kenya))
Comparison of immune responses of two Salmonella gallinarum strains viewed as possible vaccines for fowl typhoid in Kenya
1998
Bebora, L.C. | Nyaga, P.N. | Kimoro, C.O. (Nairobi Univ., Kabete (Kenya). Dept. of Veterinary Pathology and Microbiology)
The humoral immune response in cattle after immunization with a multivalent IBR/PI3/ Pasteurella haemolytica A1 leukotoxin vaccine
1997
Odendaal, M.W. (Agricultural Research Council, Onderstepoort (South Africa). Onderstepoort Veterinary Inst.) | Morris, S. | Du Preez, E. | Aitchison, H.
Seroconversion in captive African wild dogs (Lycaon pictus) following administration of a chicken head bait/SAG-2 oral rabies vaccine combination
2003
Knobel, D.L. (Edinburgh Univ., Midlothian (United Kingdom). Tropical Veterinary Medicine Centre) | Liebenberg, A. | Du Toit, J.T.
Development of a diagnostic one-tube RT-PCR for the detection of Rift Valley fever virus
2002
Espach, A. | Romito, M. (Agricultural Research Council, Onderstepoort (South Africa). Onderstepoort Veterinary Inst.) | Nel, L.H. | Viljoen, G.J.
Immune responses in a horse inoculated with the VP2 gene of African horsesickness virus
1999
Romito, M. | Du Plessis, D.H. | Viljoen, G.J. (Agricultural Research Council, Onderstepoort (South Africa). Onderstepoort Veterinary Inst.)
Protein aggregation complicates the development of baculovirus-expressed African horsesickness virus serotype 5 VP2 subunit vaccines
1998
Du Plessis, M. | Cloete, M. (Agricultural Research Council, Onderstepoort (South Africa). Onderstepoort Veterinary Inst.) | Aitchison, H. | Van Dijk, A.A.
Observations on the use of Anaplasma centrale for immunization of cattle against anaplasmosis in Zimbabwe
1998
Turton, J.A. | Katsande, T.C. | Matingo, M.B. (Department of Veterinary Services, Harare (Zimbabwe). Central Veterinary Laboratory) | Jorgensen, W.K. | Ushewokunze-Obatolu, U. | Dalgliesh, R.J.