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Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
1999
Takada, A. (Hokkaido Univ., Sapporo (Japan)) | Okazaki, K. | Kida, H.
Intranasal administration of plasmid DNA encoding glycoprotein B of pseudorabies virus into mice induced both serum and secretory antibody responses. These mice resisted intranasal challenge with lethal dose of the virus, but did not intraperitoneal challenge. On the other hand, intramuscular injection of the plasmid induced less secretory and higher serum antibody responses than those of intranasally vaccinated mice. None of them was protected from virus challenge. The present results suggest that administration of plasmid DNA encoding glycoprotein B by respiratory mucosal route generates local secretory antibodies which serve to protect animals from pseudorabies virus infection
Mostrar más [+] Menos [-]Detection of antibodies and antigens of Aujeszky's disease virus using dot-immunoassay
1994
Jun, M.H. | Cho, Y.S. | Chang, K.S. (Chungnam National University, Taejon (Korea Republic). College of Veterinary Medicine)
Identification of Aujeszky's disease virus by In situ hybridization
1994
Kim, S.B. | Sur, J.H. (Gyeongsang National University, Chinju (Korea Republic). College of Veterinary Medicine) | Moon, O.K. (Kyongnam Veterinary Service Laboratory, Chinju (Korea Republic))
