Results of studies of the influence of two biological products produced on the basis of sapropel (putrid mud) of the Ganarata lake (Mostovski district, the Republic of Belarus) on quality of legume-grass silage were presented. It was established, that analyzed preparations could be used as the preserving agents for preparation of herbal forages. The preserving action of the preparations was caused by the intensification of lactic bacteria development in silaging mass for the account of humic acids, as well as by the fungicidal action of phenolic and carboxylic fractions of the preparation. Silage preparation in combinations with putrid mud preparations made it possible to lower the losses of a crude protein on 11,3-15,6%, sugar - on 33,3%, carotin - on 20% and to obtain forage with concentration of exchange energy 9,20-9,38 mJ per 1 kg of dry matter. Silage application in combination with biological products rendered positive impact on milking efficiency of cows, the average daily milk yields in the experimental cow groups were on 1,3-1,4 kg or 6,8-7,3% higher. Application of higher quality feeds made it possible to lower the expenses of forages on 0,04 fodder units. Research results proved that the analysed preparations from sapropel could be used as an efficient conservants for silage preparations. They made it possible to raise forage quality at the minimum expenses

Evaluation of maize (Zea mays) silage prepared in combination with biological preserving agent Laktotim and calculation of its economic efficiency were realized in the conditions of the Republic of Belarus. Application of Laktotim rendered positive influence on forage dry matter content, on nutritive substance safety, and made it possible to increase the organoleptic indicators of silage. Use of the maize silage prepared with the preservative in a cow ration has positively affected their dairy efficiency. Cow milk yields have raised on 4,5%. Application of the preparation for silage making of green maize mass proved to be economically worth. The realized toxicological estimation of biological preserving agent Laktotim did not reveal any signs of preparation toxicity. Introduction of the preparation into mice stomach in a single maximum dose (25000 mg/kg; 12500; 5000 mg/kg of body weight), as well as application of the preparation in mixture with water in ratio which in 100 and 200 times exceeded the standard ratio in plant green mass, did not cause destruction of experimental animals. According to classifications of All-Union State Standard 12.1.007-76, the preparation Laktotim belongs to the4 class of danger - low-hazardous substances (LD50 over 5000 mg/kg)

Balanced complete feeding proved to be one of the major conditions of animal productivity increase and improvement of their reproductive qualities. Full value of feeding could be obtained at the expense of forage quality improvement and perfection of structure of the rations providing the increasing of metabolic energy use by breeding bull-calves. Analysis of the efficiency of metabolic energy use by the replacement bull calves under conditions of various sugar and protein ratio was realized in the Republic of Belarus. Research results showed that enrichment of replacement bull calves (with 325-405 kg of live weight) rations with easy digestible carbohydrates (sugar and starch) in ratio of 32% from a dry matter ration, including 15% of stable starch made it possible to increase the transformation of metabolic energy into energy of body weight gain on 21,73 - 23,96 MJ or on 10,3%, that as a result correspondingly increased the daily average weight gains on 7,9% and reduced the expenses for forage energy for 7,1% counting on an energy unit. According to the ejaculate volume indices the bull calves of the second experimental group surpassed analogues of a control group on 14,8%, and according to sperm concentration indices - on 12%. The average quantity of the frozen doses of sperm has made 65%

Belarus is included into number of the leading countries of the world which provide the increasing of the expansion rates of milk production and dairy products on a per capita basis. However, the agricultural enterprises of the Republic of Belarus annually spend approximately 800 thousand tons of whole milk that makes about 20% from the general milk yield for manufacturing expenditures in the process of livestock operation. The purpose of research was working out of a new premix structure and zootechnic requirements to its use in structure of milk replacer, produced on hydrodynamic installation. The optimum doses of amino acids, vitamins and mineral substances promoted the increasing of calves daily average weight gain during the dairy period on 5,4% (788,5 g instead of 748,1 g), reducing of expenses for forages per 1 kg of weight gain - on 6,5% (2,9 fodder units against 3,1 fodder units) and the decreasing of the prime cost production for fodder expenses - on 4,7%. There was presented the composition and nutritive value of the analysed whole milk replacer. Usage of local sources of protein-fatty raw materials of plant origin, and also secondary resources of processing of whole milk in the content of milk replacer for young cattle allows to completely refuse from expensive components delivered from abroad and to lower their cost

Research was directed towards selection of national, accessible and cheap ingredients of whole milk replacers in the conditions of the Republic of Belarus. The efficiency of compounding preparation and its use in calves feeding at an early age was analysed. There was developed the technological scheme of application of hydrodynamic installation which operates according cavitating principle and makes it possible to receive the homogeneous and finely divided mass directly from grain forage that is very important for preparation of milk replacer. New equipment gives the chance to lower power consumption on 17%, to receive economic benefit. During testing of developed of milk replacer-1 (used for calves feeding since one month old) and milk replacer-2 (used for calves feeding since two months old) and their comparison with the whole milk replacer Kalvolak (the Netherlands) it was revealed, that indices of a daily average weight gain in calves of the first group fed with foreign milk replacer, and in calves of the second groups, which were fed with the national milk replacer, did not show authentic differences (806 and 816 g). However, the prime cost of 1kg of live weight gain in the second case was on 43% cheaper than in the first one. The cost price of 1kg of live weight gain of calves on expenses for fodder units in trial group was on 33% cheaper in comparison with the control group

Comparative evaluation of the influence of cell-free probiotic preparation Laktimet and cellular probiotic Bifilak on productivity, livability, nonspecific response of suckling piglets in the early extrauterine life was realized in the conditions of the Republic of Belarus.Application of both probiotics increased the productivity of suckling pigs, stimulated the processes of metabolism and natural protection of organism in the early postnatal period in the conditions of specialized pig breeding complexes. Research results showed, that application of brand new cell-free probiotic Laktimet exercised higher influence on suckling pigs. Application of Laktimet made it possibler to increase piglets body weight gain on 7,8%; piglet livability - on 6,7%; and application cellular probiotic preparation Bifilak - on 5,4% and 3,3%, respectively. The same tendency was noted during the analysis of indexes of cellular factors of organism protection. Bactericidal activity of blood serum of experimental animals changed both in connection with age, and under influence of probiotic preparations. During all studied periods the bactericidal activity of blood serum was authentically (P less than 0,05) above in experimental groups in comparison with a control group. At 20-days old piglets there was stated the strengthening of bactericidal activity of blood serum. Throughout all period of experiment the superiority of trial animals over control on indicators of lysozyme activity of blood serum was observed

The comparative analysis of application of cereal ensilage produced with addition of microbial and enzymatic preserving agents Axphast Gold and Biotrof on fodder digestibility, hematological indexes and cicatrical digestion of cattle rearers was realized in the conditions of the Republic of Belarus. Cattle feeding with the analysed silage rendered positive effect on digestibility of the forage dry matter, which was on 2% higher the control index, organic matter - on 2,4%, nitrogen-free extractive substances - on 2,84%, fat - on 0,58%, protein - on 2,3%, cellulose - on 2,1%. Use in feeding of ensilaged forages from the cereal perennial grasses preserved by the microbial- enzymatic preparation produced by company Biota rendered the positive influence on use of nitrogen, calcium and phosphorus. There was also noted the increasing of the content of volatile fatty acids in paunch of young cattle silage fed with Axphast Gold that testified of more effective utilization of forage

Sodium hypochlorite solution is an effective means in control of noncontagious aetiology diseases, accompanied by development of endogen intoxications. The detoxification action of sodium hypochlorite is that in the body there is no becomes free active oxygen, oxidizing there toxic and ballast substances as bilirubin, urea, ammonia, uric acid, creatinine, cholesterol, carbonic oxide, acetone, acetone acetate, ethanol, methanol, barbiturates, etc. The detoxification action of sodium hypochlorite is shown in neutralization of exotoxins and endotoxins of pathogenic microorganisms as it represents a compound of the small molecular mass and the small structural size. In this connection it freely gets through membranes of cells and oxidizes the toxins containing not only in blood, but also in cells. From this follows, that sodium hypochlorite models not only oxidizing function of cytochrome Р-450 of liver, but also phagocytal function of neutrophilic leucocyte. It leads to inactivation of large toxic molecular compounds both on a surface of uniform elements, and in blood plasma while effective methods reduce intoxication at the expense of removal of the average molecules circulating in plasma

The effectiveness of stress prevention with use of sedative remedy Xyla in a complex with preparations Ascorbic acid with glucose, Aesel and Katosal, which improve adaptation, was researched. Application of a complex of neurotropic and adaptogenic preparations before and after dehorning promoted softening of stressful influence, that in turn has positively affected the general condition of animals and intensity of growth. Comparative test of four schemes of preventive maintenance of negative consequences of the stress caused calf dehorning, has shown their high efficiency. However more expressed stimulating influence on intensity of metabolism, antioxidant status, natural resistance, adaptation to action of stresses-factors and rates of a body weight gain were rendered by the scheme with use of preparations Aesel, Ascorbic acid with glucose and Ksila

The results of Pasteurella allocation from fur animals on the basis of studying of their cultural-morphological, biochemical properties and definition of a specific accessory are given. As a result of carrying out of bacteriological research of the pathological material received from fur animals, pure cultures have been allocated. On the basis of cultural-morphological and biochemical properties these cultures are carried to Pasteurella multocida. At serotyping these cultures Pasteurella multocida are carried to serovariants A, B and D. For selection the most important in the epizootic relation serovariants A and B Pasteurella multocida have been selected. Selected strains of serovariants A and B Pasteurella multocida had stable properties for everyone serovariant Pasteurella, that has given the basis to passport them in a collection of microorganisms to The S.N.Vyshelesskij Institute of Experimental Veterinary Medicine and a demand tax in the National centre of intellectual property at Ministerial council of Belarus on patents | Приводятся результаты выделения от пушных зверей пастерелл на основании изучения их культурально-морфологических, биохимических свойств и определение серовариантной принадлежности. В результате проведения бактериологических исследований патологического материала, полученного от пушных зверей, были выделены чистые культуры на основании культурально-морфологических и биохимических свойств и отнесены к Pasteurella multocida. При серотипизации установленные культуры Pasteurella multocida отнесены к серовариантам А, В и D. Для проведения селекции были отобраны наиболее важные в эпизоотическом отношении серовариан-ты А и В Pasteurella multocida. Селекционированные штаммы серовариантов А и В Pasteurella multocida имели стабильные свойства для каждого сероварианта пастерелл, что дало основание паспортизировать их в коллекции микроорганизмов Инстита экспериментальной ветеринарии им. С.Н. Вышелесского и подать заявки в Национальный центр интеллектуальной собственности при Совете Министров Республики Беларусь на патенты