Morphological indexes in immune system organs of piglets which were vaccinated which were immunized by SPS vaccine (against salmonellosis (Salmonella), pasteurellosis (Pasteurella) and streptococcus) in combination with immunostimulative drugs and without them were studied in the conditions of the Republic of Belarus. Piglets of the first group were vaccinated against salmonellosis, pasteurellosis and streptoccocusis by SPS vaccine. Piglets of the second group were vaccinated by SPS vaccine in combination with vitamin C. Piglets of the third group were vaccinated by SPS vaccine with immunotstimulant sodium thiosulphate. The fourth (control) group of animals was administrated with normal saline. Animals were immunized twice, intramuscularly with 7 day interval and in dose 4 ml (primary), 5 ml (secondary). Vitamin С was added in dose 0,05g per head. Research results showed that immunization by SPS vaccine with sodium thiosulphate and Vitamin С activated the morphological reaction of immune system. Application of Vitamin С and sodium thiosulphate (30% concentration) in combination with SPS vaccine promoted the increasing of lymphoid nudels in lymphodnudus and lien, increasing of plasma cells quantity in 1,3-2,2 times, activation of micro- and macrophage reaction in 1,5-2,8 times in comparison with vaccinated animals

Investigation of immunity of broiler chickens of Kobb-500 cross vaccinated by national associated viral vaccine and foreign (ABIC, Israel; Vitex XXI vek Seva) vaccines against Newcastle disease and infectious bronchitis was investigated in the conditions of the Republic of Belarus. In course of studies there was analyzed the content of immunoglobulin in blood serum, as well as the influence of living vaccines on immunity formation. Research results showed that broiler chickens immunization against Newcastle disease and infectious bronchitis by national and foreign vaccine produced by ABIC company made it possible to increase the phagocytic activity of pseudoeosinophils, bactericidalal and lysozyme activity of blood serum, that proved the activation of nonspecific protection factors. At the same time in blood serum there was stated the increasing of immunoglobulin number in 1,5-3,0 times in comparison with control groups. Economic efficiency of all analyzed vaccines was analyzed

Influence of polyphepan with lactulose on dynamics of hematological parameters for the preventive maintenance of gastroenteritis of piglets was studied in the conditions of the Republic of Belarus. Research results showed that application of the presented preparation provided normalization of haemotological parameters of blood, reduction of a level of organism intoxication that was characterized by lowering of concentration lipid peroxidation components.

Determination of chronic toxicity of a new selenium-containing preparation Aesel was realized in the conditions of the Republic of Belarus. There was realized endermatic administration of the experimental preparation to laboratory white mice. Studying of sensitivity of some organs and systems of mice and revelation of a degree of reversibility of processes caused by active substances of the drug was realized. The main clinical, pathomorphologic, biochemical, hematological changes in the organism of laboratory animals with induced chronic toxicity were determined.

Comparative effectiveness of application of SV-1 and SV-2 sorbents for preventive treatment of abomazoenterite of 1-2 month old calves was studied in the conditions of the Republic of Belarus. Research results showed that application of SV-1 and SV-2 sorbents rendered a positive influence on hematological and biochemical blood indexes, in particular, there was an increasing of hemoglobin level, albumins content, alkaline reserve, calcium and phosphorous in blood serum. They also rendered the stimulatory effect on natural resistance. The prophylactic effectiveness in experimental group was 100%, in a control one – 60%.

In the conditions of the Republic of Belarus after fasciolosis invasion of cattle for the biochemical diagnostics of liver pathologies there was composed a hepatospecific metabolic profile of blood serum of cattle into which there were included several enzymes (alanine aminotransferase; aspartate aminotransferase; gamma-glutamyl transpeptidase; alkaline phosphatase; and cholinesterase), content of total albumin, serum albumin, total cholesterin and total bilirubin, as well as colloid tests (thymol turbidity test and test for apoliproteins). There was revealed a intrahepatic cholestasis developed during fasciolosis infestation, as well as dysproteinemia as a compensatory mechanism of liver proteinsyntetic function.

Results of studying the local of irritating properties of preparative forms of marsh cinquefoil (Comarum palustre) which were intended for treatment of parasitic of diseases of animals, namely, strongylatosis of gastro-intestinal tract of sheep and calves realized in the conditions of the Republic of Belarus were presented. Preparative forms of Comarum palustre (liquor, tincture, liquid extract and powder) had poorly expressed irritating properties after application into skin of animals and weak irritating action, excluding native forms of tincture and liquid extract on mucous coat eye, that confirms their low toxicity action as a whole on organism of animals.

In degree incest negative influence of inbreeding is established on sheep's productive qualities in comparison with contemporaries with inbreeding in a degree of a close and moderate alliance. The system of a coupling of the wombs is developed, excluding inbreeding depression on productive qualities of animals and allowing to carry out repairs a livestock in a small population due to own reproduction

Usage of biological preparation of high antibacterial activity allows to decrease the air pollution by bacteria of colon bacillus group at 25-100%, increase productivity at 17-67 g, safety – at 0,4%, resistance, protein metabolism, protein fractions and some other indices (lysozyme and betalysine activity, leucocytes, erythrocytes, hemoglobin, calcium, phosphorus, iron, magnesium, AST, ALT, urea, cholesterol, bilirubin and glucose)

The analysis of swine farming production in CHUP Zopak-Agro has shown, that the decrease in the expense of forages and expenses on a payment on made production and increase of productive and breeding qualities of animals by purposeful selective-breeding work promote decrease in the cost price of a gain of live weight of pigs at the enterprise by 55,7 thousand rbl./с (or on 15,3%)