Thallium (TI) is one of the most toxic heavy metals and priority pollutant metals. The emerging TI environmental pollution worldwide has posed a great threat to human health. However, based on the World Health Organization (WHO), the risk and severity of adverse health effects of TI in the range of 5–500 μg/L are uncertain. Moreover, evidence regarding the adverse impacts of TI on children’s health is still insufficient. Herein, we aim to investigate the early adverse effects of TI on children’s health and provide references for the WHO to establish stricter safety limits of TI. From 2015 to 2019, urinary TI and many clinical laboratory parameters related to blood routine, hepatic, renal, myocardial, coagulation function and serum electrolyte were measured in six children aged 1–9 years. The urinary TI concentration ranged from 13.4 μg/L to 60.1 μg/L with a mean of 36.1 μg/L and a median of 34.8 μg/L in six children in 2015. Although only four children felt a little poor appetite, several laboratory abnormalities indicated early damage in liver, renal, and myocardial functions in all children in 2015. After treatment and following up for four years, although the children’s TI concentration decreased below 5 μg/L, their liver and renal functions did not completely recover, and their myocardial function worsened. Results indicated that impaired liver, renal, and myocardial functions were closely associated with elevated urinary TI concentration in children. Considering the increasing use of TI in high-technology industries and emerging TI environmental-contamination zones worldwide, establishing stricter safety limits of TI and paying more attention to the adverse health effects of TI on children are urgently required.We found that a relatively low concentration of thallium (13.4 μg/L to 60.1 μg/L) impaired liver, renal, and myocardial function in six children. After treatment and following up these children for four years, although their urinary TI concentration decreased below 5 μg/L, their liver and renal functions did not completely recover, and their myocardial function worsened.

Inflammasome activity plays a vital role in various non-microbial disease states correlated with prolonged inflammation. NLRP3 inflammasome function and IL-1β formation are augmented in obesity and several obesity-linked metabolic disorders (i.e. diabetes mellitus, hypertension, hepatic steatosis, cancer, arthritis, and sleep apnea). Also, several factors are associated with the progression of diseases viz. increased plasma glucose, fatty acids, and β-amyloid are augmented during obesity and activate NLRP3 inflammasome expression. Prolonged NLRP3 stimulation seems to play significant role in various disorders, though better knowledge of inflammasome regulation and action might result in improved therapeutic tactics. Numerous compounds that mitigate NLRP3 inflammasome expression and suppress its chief effector, IL-1β are presently studied in clinical phases as therapeutics to manage or prevent these common disorders. A deep research on the literature available till date for inflammasome in obesity was conducted using various medical sites like PubMed, HINARI, MEDLINE from the internet, and data was collected simultaneously. The present review aims to examine the prospects of inflammasome as a major progenitor in the progression of obesity via directing their role in regulating appetite.

With the growing appetite for reducing carbon footprint, organizations are tirelessly working towards green practices and one such crucial practice is purchasing raw materials from sustainable suppliers (SSs). Inspired by the drift in purchase habits, several sustainable suppliers emerged in the market and a rational selection of a suitable sustainable supplier is a complex decision problem. There are many criteria associated with the evaluation of sustainable suppliers, and double hierarchy hesitant fuzzy linguistic (DHHFL) structure is a popular preference style that accepts complex linguistic expressions in the natural language form. Earlier studies on sustainable supplier selection infer that (i) complex linguistic expressions are not properly modeled, (ii) interrelationship among criteria must be considered during importance assessment, (iii) direct assignment of attitudinal values of experts causes bias and subjectivity, and (iv) nature of criteria play a crucial role in ranking SSs. To overcome these limitations, a novel MCMD framework is proposed in this study in which the attitudinal characteristic values of experts are calculated by using a variance approach. Besides, importance of diverse sustainable criteria is calculated by proposing novel attitude-CRITIC approach that supports proper capturing of interrelationship among criteria along with experts’ attitude values. Later, weighted distance approximation algorithm is presented to DHHFL setting for personalized and cumulative ranking of SSs by properly considering nature of criteria. These methods are integrated to form a framework under DHHFL setting, and its usefulness is exemplified by using a case study of SS selection in an automotive firm. A comprehensive sensitivity analysis as well performed to test the validity of the proposed model approves the applicability, validity, and robustness of the model. Lastly, comparison is done with other methods to understand the merits and shortcomings of the proposal.

This is the first study from Pakistan to report the exposure of petrol filling workers (n = 120) to naphthalene (Nap) and pyrene (Pyr) in relation to their functional capacities and health outcome. A group of non-exposed subjects (controls n = 46) was also recruited for comparison. The perceived health risk of the exposed workers was monitored using a questionnaire based on the self-reporting survey. The observed physical anomalies related to the health disorder included the acidity after meals, eye redness, appetite loss, skin lesions, and dryness of oral cavity, while those related to neurasthenic symptoms included the body aches, energy loss, twitching, fatigue, sleeplessness, fainting, and irritability. Mean Nap level observed in the exposed group (106 μg L⁻¹) was significantly correlated (r = 0.49; p < 0.01) with cigarette smoking, while the average Pyr concentration (19.18 μg L⁻¹) was associated with job duration. Workers exposed for 6 h per day or more had significantly high prevalence of physical disorders (OR = 2.79, 95% CI = 1.28–6.09). Neurasthenic symptoms were found in 65% of the subjects and were associated with years of involvement in job. Ten years or more work duration at petrol pumps could be associated with a substantial development of neurasthenic effects (OR = 2.80, 95% CI = 1.23–6.34). In conclusion, the subjects ascribed the disturbances in physical and neurological behavior to their occupation (petrol filling) and also rated their overall health and functional capacity as poor. To promote health of petrol pump workers, reduction in work hours and provision of masks and gloves could be introduced as occupational health interventions.