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A spatio-temporally weighted hybrid model to improve estimates of personal PM2.5 exposure: Incorporating big data from multiple data sources
2019
Ben, YuJie | Ma, FuJun | Wang, Hao | Hassan, Muhammad Azher | Yevheniia, Romanenko | Fan, WenHong | Li, Yubiao | Dong, ZhaoMin
An accurate estimation of population exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM₂.₅) is crucial to hazard assessment and epidemiology. This study integrated annual data from 1146 in-home air monitors, air quality monitoring network, public applications, and traffic smart cards to determine the pattern of PM₂.₅ concentrations and activities in different microenvironments (including outdoors, indoors, subways, buses, and cars). By combining massive amounts of signaling data from cell phones, this study applied a spatio-temporally weighted model to improve the estimation of PM₂.₅ exposure. Using Shanghai as a case study, the annual average indoor PM₂.₅ concentration was estimated to be 29.3 ± 27.1 μg/m³ (n = 365), with an average infiltration factor of 0.63. The spatio-temporally weighted PM₂.₅ exposure was estimated to be 32.1 ± 13.9 μg/m³ (n = 365), with indoor PM₂.₅ contributing the most (85.1%), followed by outdoor (7.6%), bus (3.7%), subway (3.1%), and car (0.5%). However, considering that outdoor PM₂.₅ makes a significant contribution to indoor PM₂.₅, outdoor PM₂.₅ was responsible for most of the exposure in Shanghai. A heatmap of PM₂.₅ exposure indicated that the inner-city exposure index was significantly higher than that of the outskirts city, which demonstrated that the importance of spatial differences in population exposure estimation.
Mostrar más [+] Menos [-]Emissions from a fast-pyrolysis bio-oil fired boiler: Comparison of health-related characteristics of emissions from bio-oil, fossil oil and wood
2019
Sippula, Olli | Huttunen, Kati | Hokkinen, Jouni | Kärki, Sara | Suhonen, Heikki | Kajolinna, Tuula | Kortelainen, Miika | Karhunen, Tommi | Jalava, Pasi | Uski, Oskari | Yli-Pirilä, Pasi | Hirvonen, Maija-Riitta | Jokiniemi, Jorma
There is currently great interest in replacing fossil-oil with renewable fuels in energy production. Fast pyrolysis bio-oil (FPBO) made of lignocellulosic biomass is one such alternative to replace fossil oil, such as heavy fuel oil (HFO), in energy boilers. However, it is not known how this fuel change will alter the quantity and quality of emissions affecting human health. In this work, particulate emissions from a real-scale commercially operated FPBO boiler plant are characterized, including extensive physico-chemical and toxicological analyses. These are then compared to emission characteristics of heavy fuel-oil and wood fired boilers. Finally, the effects of the fuel choice on the emissions, their potential health effects and the requirements for flue gas cleaning in small-to medium-sized boiler units are discussed.The total suspended particulate matter and fine particulate matter (PM₁) concentrations in FPBO boiler flue gases before filtration were higher than in HFO boilers and lower or on a level similar to wood-fired grate boilers. FPBO particles consisted mainly of ash species and contained less polycyclic aromatic hydrocarbons (PAH) and heavy metals than had previously been measured from HFO combustion. This feature was clearly reflected in the toxicological properties of FPBO particle emissions, which showed less acute toxicity effects on the cell line than HFO combustion particles. The electrostatic precipitator used in the boiler plant efficiently removed flue gas particles of all sizes. Only minor differences in the toxicological properties of particles upstream and downstream of the electrostatic precipitator were observed, when the same particulate mass from both situations was given to the cells.
Mostrar más [+] Menos [-]Mutagenic and genotoxic effects induced by PM0.5 of different Italian towns in human cells and bacteria: The MAPEC_LIFE study
2019
Bonetta, Sara | Bonetta, Silvia | Schilirò, Tiziana | Ceretti, Elisabetta | Feretti, Donatella | Covolo, Loredana | Vannini, Samuele | Villarini, Milena | Moretti, Massimo | Verani, Marco | Carducci, Annalaura | Bagordo, Francesco | De Donno, Antonella | Bonizzoni, Silvia | Bonetti, Alberto | Pignata, Cristina | Carraro, Elisabetta | Gelatti, Umberto | Gilli, G. | Romanazzi, V. | Gea, M. | Festa, A. | Viola, G.C.V. | Zani, C. | Zerbini, I. | Donato, F. | Monarca, S. | Fatigoni, C. | Levorato, S. | Salvatori, T. | Donzelli, G. | Palomba, G. | Casini, B. | De Giorgi, M. | Devoti, G. | Grassi, T. | Idolo, A. | Panico, A. | Serio, F. | Furia, C. | Colombi, P.
Particulate matter (PM) is considered an atmospheric pollutant that mostly affects human health. The finest fractions of PM (PM2.5 or less) play a major role in causing chronic diseases.The aim of this study was to investigate the genotoxic effects of PM0.5 collected in five Italian towns using different bioassays. The role of chemical composition on the genotoxicity induced was also evaluated.The present study was included in the multicentre MAPEC_LIFE project, which aimed to evaluate the associations between air pollution exposure and early biological effects in Italian children.PM10 samples were collected in 2 seasons (winter and spring) using a high-volume multistage cascade impactor. The results showed that PM0.5 represents a very high proportion of PM10 (range 10–63%). PM0.5 organic extracts were chemically analysed (PAHs, nitro-PAHs) and tested by the comet assay (A549 and BEAS-2B cells), MN test (A549 cells) and Ames test on Salmonella strains (TA100, TA98, TA98NR and YG1021).The highest concentrations of PAHs and nitro-PAHs in PM0.5 were observed in the Torino, Brescia and Pisa samples in winter. The Ames test showed low mutagenic activity. The highest net revertants/m3 were observed in the Torino and Brescia samples (winter), and the mutagenic effect was associated with PM0.5 (p < 0.01), PAH and nitro-PAH (p < 0.05) concentrations. The YG1021 strain showed the highest sensitivity to PM0.5 samples. No genotoxic effect of PM0.5 extracts was observed using A549 cells except for some samples in winter (comet assay), while BEAS-2B cells showed light DNA damage in the Torino, Brescia and Pisa samples in winter, highlighting the higher sensitivity of BEAS-2B cells, which was consistent with the Ames test (p < 0.01).The results obtained showed that it is important to further investigate the finest fractions of PM, which represent a relevant percentage of PM10, taking into account the chemical composition and the biological effects induced.
Mostrar más [+] Menos [-]Characteristics of air pollutants inside and outside a primary school classroom in Beijing and respiratory health impact on children
2019
Zhang, Lulu | Morisaki, Hiroshi | Wei, Yongjie | Li, Zhigang | Yang, Lu | Zhou, Quanyu | Zhang, Xuan | Xing, Wanli | Hu, Min | Shima, Masayuki | Toriba, Akira | Hayakawa, Kazuichi | Tang, Ning
This study investigated the spatial and temporal distributions of particulate and gaseous air pollutants in a primary school in Beijing and assessed their health impact on the children. The results show that air quality inside the classroom was greatly affected by the input of outdoor pollutants; high levels of pollution were observed during both the heating and nonheating periods and indicate that indoor and outdoor air pollution posed a threat to the children's health. Traffic sources near the primary school were the main contributors to indoor and outdoor pollutants during both periods. Moreover, air quality in this primary school was affected by coal combustion and atmospheric reactions during the heating and nonheating periods, respectively. Based on the estimation by exposure-response functions and the weighting of indoor and outdoor pollutants during different periods, the levels of PM2.5, PM 10 and O3 at school had adverse respiratory health effects on children. Longer exposures during the nonheating period contributed to higher health risks. These results emphasized that emission sources nearby had a direct impact on air quality in school and children's respiratory health. Therefore, measures should be taken for double control on air pollution inside and outside the classroom to protect children from it.
Mostrar más [+] Menos [-]Persistence of elevated concentrations of PM, affiliated pharmaceuticals, and tetracycline resistance genes downwind of feedyards
2019
Wooten, Kimberly J. | Mayer, Gregory D. | Smith, Philip N.
Beef cattle feedyards have been identified as sources of large amounts of particulate matter (PM) which may transport affiliated chemicals including steroids, beta agonists, and antibiotics from feedyards into the environment. This study is the first to examine persistence of PM-affiliated pharmaceuticals downwind of feedyards using multiple downwind samples collected at increasing distances from feedyard boundaries (n = 5). Concentrations of antibiotics and ractopamine per gram of PM remained consistent at all downwind locations (out to 4.8 km) whereas concentrations per m³ air decreased significantly at distances between 0.1 and 0.7 km downwind, corresponding to significant decreases in mass of PM. Monensin was present in the highest concentrations of any measured pharmaceutical, with concentrations of 37 μg/g PM (376 ng/m³) air in samples collected within 0.1 km downwind of feedyards. Total copy count of tetracycline resistance genes (tetW, tetQ, tetO, tetM, tetL, and tetB) were also significantly increased in samples collected within 0.1 km downwind of feedyards (10⁶ copies) as compared to samples collected upwind (10³ copies) and farther downwind (10⁴ copies) of feedyard boundaries. These results suggest that transport of pharmaceutical-laden PM into the terrestrial environment is occurring primarily via PM deposition within 0.7 km of the feedyard, while aerial transport persists over longer distances (>4.8 km).
Mostrar más [+] Menos [-]Impacts of air pollution on dry eye disease among residents in Hangzhou, China: A case-crossover study
2019
Mo, Zhe | Fu, Qiuli | Lyu, Danni | Zhang, Lifang | Qin, Zhenwei | Tang, Qiaomei | Yin, Houfa | Xu, Peiwei | Wu, Lizhi | Wang, Xiaofeng | Lou, Xiaoming | Chen, Zhijian | Yao, Ke
The purpose of this study is to investigate the potential associations between air pollution and dry eye disease (DED). Data of outdoor air pollutants and meteorology as well as outpatient visits for DED were collected. A time-stratified case-crossover approach was used to analyze the associations between ambient air pollutants and outpatient visits for DED. Among the 5062 DED patients studied, 65.45% were female and 34.55% were male. In the single-pollutant model, significant associations were observed between an increase of 10 μg/m³ in the concentrations of fine-particulate matter with a median aerometric diameter of less than 10 μm (PM₁₀), fine-particulate matter with a median aerometric diameter of less than 2.5 μm (PM₂.₅), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), and carbon monoxide (CO) and outpatient visits for DED. These results were consistent with those of the multipollutant model. The strongest associations between air pollutants and patient visits were observed during the cold season and in patients aged 21–40. The significant association between air pollutants (PM₁₀, PM₂.₅, SO₂, NO₂, and CO) and DED outpatient visits indicates the importance of increased environmental protection.
Mostrar más [+] Menos [-]Satellite-derived PM2.5 concentration trends over Eastern China from 1998 to 2016: Relationships to emissions and meteorological parameters
2019
Gui, Ke | Che, Huizheng | Wang, Yaqiang | Wang, Hong | Zhang, Lei | Zhao, Hujia | Zheng, Yu | Sun, Tianze | Zhang, Xiaoye
Fine particulate matter (PM₂.₅) pollution in Eastern China (EC) has raised concerns due to its adverse effects on air quality, climate, and human health. This study investigated the long-term variation trend in satellite-derived PM₂.₅ concentrations and how it was related to pollutant emissions and meteorological parameters over EC and seven regions of interest (ROIs) during 1998–2016. Over EC, the annual mean PM₂.₅ increased before 2006 due to the enhanced emissions of primary PM₂.₅, NOₓ and SO₂, but decreased with the reduced SO₂ emissions after 2006 evidently in response to China's clean air policies. In addition, results from statistical analyses indicated that in the North China Plain (NCP), Northeast China (NEC), Sichuan Basin (SCB) and Central China (CC) planetary boundary layer height (PBLH) was the dominant meteorological driver for the PM₂.₅ decadal changes, and in the Pearl River Delta (PRD) wind speed is the leading factor. Overall, the variation in meteorological parameters accounted for 48% of the variances in PM₂.₅ concentrations over EC. The population-weighted PM₂.₅ over EC increased from 36.4 μg/m³ in 1998–2004 (P1) to 49.4 μg/m³ in 2005–2010 (P2) then decreased to 46.5 μg/m³ in 2011–2016 (P3). In the NCP and NEC, the percentages of the population living above the World Health Organization (WHO) Interim Target-1 (IT-1, 35 μg/m³) have risen steadily over the past 20 yr, reaching maxima of 97.3% and 78.8% in P3, respectively, but decreases of ∼30% from P2 to P3 were found for the SCB and PRD.
Mostrar más [+] Menos [-]PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance
2019
Wang, Yan | Tang, Meng
PM2.5 is becoming a worldwide environmental problem, which profoundly endangers public health, thus progressively capturing public attention this decade. As a fragile target of PM2.5, the underlying mechanisms of endothelial cell damage are still obscure. According to the previous microarray data and signaling pathway analysis, a new form of cell death termed ferroptosis in the current study is proposed following PM2.5 exposure. In order to verify the vital role of ferroptosis in PM2.5-induced endothelial lesion and further understand the potential mechanism involved, intracellular iron content, ROS release and lipid peroxidation, as well as biomarkers of ferroptosis were detected, respectively. As a result, uptake of particles increases cellular iron content and ROS production. Meanwhile, GSH depletion, and the decrease of GSH-Px and NADPH play significant roles in PM2.5-induced endothelial cell ferroptosis. Moreover, significantly changed expression of TFRC, FTL and FTH1 hinted that dysfunction of iron uptake and storage is a major inducer of ferroptosis. Importantly, index monitored above can be partially rescued by lipid peroxidation inhibitor ferrostatin-1 and iron chelator deferoxamine mesylate, which mediated antiferroptosis activity mainly depends on the restoration of antioxidant activity and iron metabolism. In conclusion, our data basically show that PM2.5 enhances ferroptosis sensitivity with increased ferroptotic events in endothelial cells, in which iron overload, lipid peroxidation and redox imbalance act pivotal roles.
Mostrar más [+] Menos [-]TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon
2019
Cheng, Zhiyuan | Chu, Hongqian | Wang, Siqi | Huang, Yao | Hou, Xiaohong | Zhang, Qi | Zhou, Wenjuan | Jia, Lixia | Meng, Qinghe | Shang, Lanqin | Song, Yiming | Hao, Weidong | Wei, Xuetao
Black carbon (BC) can combine with organic matter and form secondary pollutants known as aged BC. BC and aged BC can cause respiratory system inflammation and induce lesions at relevant sites, but the underlying mechanism has remained unknown. To gain insight into the potential mechanisms, we focused on macrophages and transforming growth factor β-activated kinase 1 (TAK1) which are a crucial factor in inflammation. Our research aims to determine the role of TAK1 in macrophages in pulmonary inflammation induced by particulate matter. In this study, BC and 1,4-naphthoquinone were mixed to model aged BC (1,4NQ-BC) in atmosphere. BC induced mice lung inflammation model, lung macrophage knock-down TAK1 animal model and primary macrophage knock-down TAK1 model were used to explore whether TAK1 in macrophage is a critical role in the process of inflammation. The results showed that the expressions of inflammatory cytokines (IL-1β, IL-6, IL-33) mRNA were significantly increased and the phosphorylation of MAPK and NF-κB signaling pathway related proteins were enhanced in RAW 264.7 cell lines. In vivo studies revealed that the indicators of pulmonary inflammation (pathology, inflammatory cell numbers) and related cytokines (IL-1β, IL-6, IL-33) mRNA expressions in CD11c-Map3k7⁻/⁻ animals were significantly lower than wild-type animals after mice were instilled particles. In mice primary macrophages, the expressions of IL-6, IL-33 mRNA were inhibited after TAK1 gene was knock-down. These results unequivocally demonstrated that TAK1 plays a crucial role in BC induced lung inflammation in mice, and we can infer that BC and 1,4NQ-BC cause these inflammatory responses by stimulating pulmonary macrophages.
Mostrar más [+] Menos [-]Diurnal trends in redox characteristics of water-soluble and -insoluble PM components
2019
Gali, Nirmal Kumar | Li, Guoliang | Ning, Zhi | Brimblecombe, Peter
Densely populated cities with a compact urban built environment have concerns over health risks derived from high levels of airborne particulate matter (PM) exposure. Understanding the association between PM and reactive oxygen species (ROS) is an important step towards unravelling the mechanisms behind. This study investigated the role of time-integrated PM sampling on cellular toxicity mechanism on a diurnal scale. The sampling took place in a highly urbanized part of Hong Kong at two contrast roadside and background sites, with simultaneous solid-PM and semi-volatile-PM (SV-PM) collection in both summer and winter seasons. A sampling day consisted three sampling intervals of 6 h each – 04:00–10:00, 12:00–18:00 and 20:00–02:00 h, representing morning rush hours, afternoon and night periods, respectively. Water and organic extracts of PM were prepared, with and without filtration, and exposed to RAW264.7 and A549 cell lines on a dose and time-dependent manner. Solid-PM and SV-PM contribution to total PM₂.₅ mass concentration was 9:1, with much higher SV-PM fraction at roadside over urban background (p < 0.001, n = 36). Also, the SV-PM mass concentration increased by 10–20% during 20:00–02:00 h compared to morning and afternoon sampling periods. Organic PM extract was observed to cause 23–29% higher cell death compared to water-soluble PM, which is complemented with increased ROS production in both cell lines. The cellular damage caused by oxidative stress, determined from increased HO-1 and TNF-α expression in RAW264.7 was higher compared to the A549, which demonstrated the greater induction of toxicity from organic PM extract over soluble PM. Similarly, the SV-PM induced greater than 2-fold cellular ROS generation on PM mass basis compared to solid-PM. Lack of phagocytic action in A549 compared to RAW264.7 suggested novel toxicity routes for water-soluble and organic PM that can be expected to occur during human PM inhalation-bronchi-alveolar exposure.
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