The aim of this study was to investigate the effects of resveratrol extract (RE) and curcumin extract (CE) added to diet on the serum biochemical parameters and hepatic enzyme levels as Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), and Gamma Glutamyl Transferase (GGT) of broiler. A total number of 200, 0-day-old male broiler chicks (Ross 308) were used in the study. The animals were divided into 5 groups; the control group was fed only basal diet but groups RE-1, RE-2, CE-1 and CE-2 had 250 mg/kg RE, 500 mg/kg RE, 250 mg/kg CE and 500 mg/kg CE, respectively, added to their diets. At the end of the study, 10 randomly selected animals from each group were slaughtered and blood was taken from the vena jugularis and used in the analysis. In the examinations, it was determined that the serum creatinine level in the group RE-1 and the Lactate Dehydrogenase (LDH) level increased significantly in the group CE-2 group. In addition, it was determined that the albumin/globulin ratio in the RE-2 group, and the magnesium (Mg) level increased significantly in the RE-1 and RE-2 groups. It was found to be statistically similar in all groups that serum glucose, cholesterol, triglyceride, urea, blood urea nitrogen (BUN), creatine kinase (CK), ALT, AST, ALP, GGT, amylase, total protein, albumin, globulin, calcium (Ca) and phosphorus (P) levels. As a result, it was observed that the additives applied did not have an effect on serum hepatic enzymes and partially affected other routine biochemical parameters.