Kanser tedavisinde kullanılan ilaçların etkileri yalnızca kanser hücrelerine özgü olmayıp sağlıklı hücreleri de olumsuz etkilemektedir. Bu çalışmada antikanser bir ilaç olan paklitaksel’in (PAX) böbrek dokusundaki olası zararlı etkilerine karşı antioksidan etkileriyle öne çıkan silimarin’in (SLY) olası koruyucu etkilerinin ortaya konulması amaçlandı. Toplam 28 adet Sprague-Dawley cinsi dişi sıçandan rastgele bir seçimle: Kontrol, PAX, SLY ve PAX + SLY olmak üzere dört grup (n=7) oluşturuldu. PAX grubuna 2 mg/kg intraperitoneal yolla PAX, SLY grubuna oral gavaj sonda ile 100 mg/kg SLY, PAX + SLY grubuna ise önceki gruplarla aynı doz ve yolla PAX ve SLY uygulandı. Deneysel işlemlerin sonunda hayvanlardan alınan kan ve böbrek dokularında yapılan biyokimyasal analizlerde PAX’ın, böbrek dokusunda oksidatif stresi, serumda ise kreatinin (Cr) ve kan üre azotu (blood urea nitrogen, BUN) seviyelerini artırdığı tespit edildi. Böbrek dokusunda yapılan histopatolojik incelemelerde PAX’ın renal korpüskül atrofisi, fırçamsı kenarda hasar, vakuolar dejenerasyon ve deskuamasyon gibi patolojik değişikliklere yol açtığı gözlendi. Antienflamatuar, antiapoptotik ve antioksidan etkilere sahip bir farmakolojik ajan olan SLY uygulanması ise, PAX kullanımı sonucu meydana bu gelen patolojik değişiklikleri büyük oranda engelledi. Mevcut çalışmada elde edilen sonuçlar PAX ile yapılacak tedavilerde böbrek dokusunda şekillenecek zararlı etkilere karşı koruyucu olarak SLY’nin kullanılabileceğini gösterdi.

In this study, the morphological body characteristics of hair goats bred in Isparta province, such as withers height, back height, rump height, chest width and body length, were investigated. The animal material of the study consisted of 45 hair goats in 3 farms in total, in lowland conditions, high pasture and highland conditions in the center of Isparta. In the examinations, it was found that the measurements of the males were longer than the measurements of the females in terms of withers, back and rump height, chest circumference and body length, respectively. While the difference was found to be significant in terms of withers height, back height, rump height, and body length (p

İklim değişikliğinin toprak erozyonu da dâhil olmak üzere daha şiddetli çevresel problemlere yol açması beklenmektedir. Bu araştırmada Yeşilırmak Havzasın da toprak erozyonu yoluyla meydana gelen sediment verimi ve sediment tutma kapasitesi üzerine iklim değişikliğinin etkilerinin InVEST sediment iletim modeli ile incelenmesine yöneliktir. Araştırmada İklim değişikliğinin toprak erozyonu üzerine etkilerinin incelenmesi için GFDL-CM3 (Jeofiziksel Akışkanlar Dinamiği Laboratuvarı İklim Modeli Sürüm III) genel dolaşım modelinin RCP4.5 ve RCP8.5 senaryoları kullanılmıştır. 2070’ li yıllara kadar Yeşilırmak Havzasında referans döneme göre sediment veriminde ve sediment tutunma oranlarında sırasıyla %9,48 ve %12,47 düzeyine varan azalışlar öngörülmüştür. Toprak erozyonu oranlarındaki azalmanın temel sebebi yağış miktarlarındaki düşüşlerden kaynaklanan yağış erozovitesindeki azalmadan kaynaklanmaktadır ve bu azalmanın etkisi sulak alan sistemlerine ve tarım arazilerine olumlu şekilde yansıması öngörülmüştür. Ayrıca, bu araştırma gelecekteki iklim değişikliğinin toprak erozyonuna olası etkilerinin mekânsal ve zamansal olarak tahmin edilmesinde InVEST model yaklaşımının avantajlarına işaret etmektedir.

This is study is based with the support of RS-GIS technology on the land use of Samsun Center, as well as the coastal districts of Ilkadım,Atakum,Bafra Plain, through the processing and interpretation of satellite images in the summer months of 2000,2010,2020. Spatial and temporal variability properties of LU/LC were determined using MLC algorithm, controlled classification approach. The predictive values of the LU/LC change that will occur in 2030, calculated with the MLP‑ANN model based on Machine Learning algorithms and mapped with the QGIS 3.16 program. To determine the accuracy coefficient of the model, 2020 LU/LC simulation performed using the transition potential matrix of 2000 and 2010 LU/LC data. The results of simulation were compared the data of land use land cover with the 2020 to evaluate the accuracy of the simulation model. The model of MLP‑ANN provided an accuracy of 72% based on the kappa fit index. According to MLP‑ANN model 2030 results were an increase of 73.33 km² in built up areas, an increase of 56.89 km² in bare areas, and a decrease of 129.66 km² in green areas. It provided a reference basis for future Samsun urban to rural coastline LU planning and management and LU structure optimization.

The present study, it was aimed to determine the effect of antioxidants added to culture media on blastocyst development rates in in vitro embryo production. The material of the study consisted of oocytes collected from the ovaries taken from the slaughterhouse. Cumulus oocyte complexes (COC) were collected and classified under a stereomicroscope. Oocytes included in the study were subjected to maturation and fertilization stages. Probable zygotes were transferred to the culture (IVC) containing antioxidants (L-ergothionine 100 μM (n: 163), Vitamin E 100 μM (n: 151) Cysteamine 50 μM (n: 154) and were cultured in a tri gas incubator (Hera Cell- 6% O2%, 6%CO2, 88%N). Blastocyst rates and embryo quality were determined on the 6th and 7th days in culture medium. Differences in IVMFC stages were evaluated by chi-square test. 966 oocytes were collected from 162 ovaries collected from the slaughterhouse. It was determined that the number of oocytes per ovary was 5,96, and the number of A and B quality oocytes was 4.26. It was determined that 655 (94.93%) of a total of 690 oocytes undergoing in vitro maturation were mature. The cleavage rates of the groups were 83.44%; 80.79%; 79.87%, and 83.96%, respectively. 140 (21.37%) blastocysts were obtained from 655 oocytes taken into the culture stage and the blastocyst rates in the groups were 33.13%; 8.61%; 7.79%, and 32.62%, respectively. As a result of the study, it was determined that the rates of blastocysts in the L-ergothioneine added the group was similar to the control group, but the blastocyst rates decreased significantly in the cysteamine and Vitamin E added groups. It was thought that this decrease might have been affected by the dose of antioxidants or the adequacy of oocyte development

In recent years the number of phytoplasma diseases that negatively affect yield and quality of many plants has been increasing around the world. As is known grafting, plant propagation materials (seed, bulb, tuber), parasitic plants and insect vectors play active role in the spread of phytoplasmas causing these diseases. These organasim which get through plate in the sieve tube element and systemically colonize the plant, it invade and multiply salivary glands, midgut, heomocel, brain and fat tissue after sucking up insect body with stylet. Subsequently they continue the cycle by moving to a new plant with a diseased insect feeding on a healthy plant. Although the existence of functional genomics in this cycle is known, there is little information about transmission of phytoplasma from vector to host plant or from host plant to vector, the mechanism of disease caused by phytoplasma in the plant and genomics involved in different reactions in the host plant against phytoplasmal infection.

In this study, we aimed to determine the therapeutic value of local Yığılca honeys by examining their physicochemical characteristics, phenolic content, radical scavenging activity, and antimicrobial properties by underlining some overlooked parameters. Honey samples ware divided into two main groups as CH and FH based on melissopalynologycal analysis. Antimicrobial activity of collected honey samples were investigated on important hospital-acquired infections bacteria strains; MRSA (Methicillin-resistant Staphylococcus aureus), MSSA (Methicillin-sensitive Staphylococcus aureus), Escherichia coli, and Acinetobacter baumannii. Although CH’s antimicrobial activities were found slightly higher than the FH’s, there isn’t statistically significant differences between two type honeys. However, the antioxidant activity of CH was found significantly higher than FH. Surprisingly, a higher amount of isomaltose was determined in addition to the total phenolic content in CH compared to FH. There has been found positive correlation between isomaltose amount and zone diameters for MRSA and A. baumannii. We would like to draw attention to isomaltose for its health benefit structure since these parameters may be influence honey’s therapeutic value. We recommend that isomaltose and invertase enzyme should be included in to the honey codex standards suitably depending on the monofloral and multifloral honey’s specific structure, to sensitively standardize and control their quality and therapeutic value. Our data revealed a positive correlation between antioxidant and antimicrobial activity and total phenolic content and higher isomaltose amount.

We, here, aimed to determine the presence of Anguillicola crassus, a swim bladder parasite, in 89 (male: 45, female: 44) dead European eel specimens obtained seasonally between 2020-2021 from a regional fisherman, who has fished with fyke net in the locality Tuzla of Izmir Bay, Eastern Aegean Sea. Out of 21 male European eels caught in winter, only one specimen (TL: 48.5 cm and TW: 247.12 g) had 23 swim bladder parasites (adult nematodes: 15, larvae: 8) and similarly, only one parasite was found in one specimen (TL: 37.5 cm and TW: 88.47 g) of 8 eels caught in spring. No parasite was found in the female eels. At the examinations, it was determined that all adult Anguillicola crassus specimens were females and the minimum-maximum and average length values in adult and larval parasites were, respectively, 1.5-2.5 cm (1.99 ± 0.31) and 0.7-1.3 cm (1.025 ± 2.40). Consequently, the species A. crassus, a swim bladder parasite, was found in European eels from the locality Çamalti Tuzla in two seasons (winter and spring) and this parasitic nematode were only in male eels. This study is a first and remarkable one having evidential value, which shows the presence of the species A. crassus among the eel population in the locality Çamalti Tuzla of Izmir Bay. Besides, it is a population that should be monitored due to the status of Anguilla anguilla on the IUCN red list.

Organic agricultural products are food products that are inspected and certified at all stages of production until they are offered for consumption by institutions that are authorized by the state. Beekeeping products made for human food are also subject to the same certification process. With this research, it was aimed to reveal the organic beekeeping and organic honey understanding of the people of Iğdır region. With the survey, the information of the local consumers about organic honey, how they got this information, their status and reasons for organic honey consumption, as well as the certification processes were collected. The obtained data were analyzed with numerical, proportional, and decision tree methods. The genders of the survey participants were 66% male, 34% female. It was also determined that 70.5% of the participants were under the age of 40, had a bachelor's degree or higher education level in the proportion of 43%, and 63% had a minimum wage or lower-income level. For the questions asked about the research topic, it was reported that participants know and eat organic honey in the proportion of 93%, buy organic honey in the proportion of 77.5%, having information about the organic honey certificate in the proportion of 67% and certification stages in the proportion of 43%. Despite these high rates, the same participants gave contradictory answers to some other questions, such as; for the question of “What is organic honey?” the answer of "Certified honey" in the proportion of only 11.5% and for the question of “How did you know that the organic honey you bought was organic honey?” the answer of " I saw its certificate” in the proportion of only 18.1%. This contradiction was noted. With this research, it was determined that the local people did not have enough information about organic beekeeping and honey understanding. In order to fill this gap, it can be suggested that healthy nutrition lessons be included in the education curricula starting from primary school, and usage of TV, radio, and internet broadcasting for this purpose. The fact that the participants' education level is high and their age is young may provide an advantage in order to get results from the training to be given on the subject.

Labneh is one of the most consumed dairy products in the Lebanese community, on breakfast, as a snack or on dinner, plane or mixed with herbs. Its various health benefits plus its acceptability among people makes it an important part of the Lebanese diet. In both its synthetic and homemade forms, several additives are usually incorporated to enhance its flavor and offer a variety of tastes. The problem with Labneh is its short shelf life, as well as its sensitive sensory profile. That is why most industries mix chemical additives with Labneh to prolong its shelf life and conserve its taste. The aim of this research is to preserve Labneh naturally by adding Moringa Oleifera dried leaves to extend its shelf life and inhibit rapid spoilage. Working on a natural preservation of Labneh instead of chemical preservation will be assessed by the survey’s results and prepare for studying the overall acceptability of the product by making a sensory analysis. The results of the questionnaire showed that the Lebanese community which is not totally aware of Moringa Oleifera benefits and availability, is willing to try fortified Labneh with Moringa as a new product with extended shelf life and more health benefits. The results of the sensory analysis showed that the sensory attributes of the samples with Moringa after 21 days of storage, where not significantly different than normal plane Labneh, which indicate that adding Moringa did not affect the sensory attributes of Labneh giving it more acceptability to consumers.