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Ashish Pratap Singh(Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Uttar Pradesh (India). College of Veterinary Science and Animal Husbandry. Department of Veterinary Medicine) | Arvind Kumar Tripathi(Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Uttar Pradesh (India). College of Veterinary Science and Animal Husbandry. Department of Veterinary Medicine) | Rudra Pratap Pandey(Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Uttar Pradesh (India). College of Veterinary Science and Animal Husbandry. Department of Veterinary Medicine) | Ashish Srivastava(Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Uttar Pradesh (India). College of Veterinary Science and Animal Husbandry. Department of Veterinary Medicine)

In present investigation therapeutic efficacy of three most commonly used anti-trypanosomal drugs (isometamidium chloride hydrochloride, diminazine aceturate, and quinapyramine sulphate) were studied. Evaluations of therapeutic efficacy were assessed done on the basis of percent recovery assessment, hematological and biochemical alteration on day 0, day 7th and day 14th post treatment. All three drugs were found effective against the trypanosomosis in buffalo but the extent of improvement in terms of hematological values, biochemical values and percent recovery was observed maximum in the treatment with isometamidium chloride hydrochloride followed by diminazene aceturate and least with the quinapyramine sulphate.

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