The major landslide of 2010 in Bududa district in Eastern Uganda is the most catastrophic natural disaster in Uganda's recorded history. An estimated 350 people died and some of the affected were resettled in Kiryandongo district. We assessed housing, water and sanitation practises of affected households and controls to establish possible implications on food insecurity and diet diversity.This cross-sectional study assessed 1078 affected and control households in Bududa and Kiryandongo districts. The head of the households were either affected, selected from landslide disaster-affected communities, or controls from a random sub-county bordering the affected. Structured interviews were used and entries were tested statistically to report crude estimates based on the Pearson x² and ANOVA, while adjusted analysis used multivariate analysis of co-variance (MANCOVA) and Wald's Odds Ratio (OR) of Binary Logistic Regression at the 95% CI.On adjusting for the disaster and covariates, households who had insufficient access to water scored higher mean (SE) on food insecurity than those who reported sufficient access: 13.1 (0.4) vs. 9.5 (0.3) (P < 0.01). Intriguingly, households who owned a toilet and those who reported always using soap to wash hands scored higher food insecurity than their counterparts: 11.1 (0.3) vs. 9.0 (0.6) (P < 0.01) and 11.3 (0.3) vs. 9.1 (0.5) (P < 0.01), respectively. However, not owning a toilet increased the likelihood of being food insecure (OR 3.43; 95% CI 1.31, 8.97; P = 0.02). In Kiryandongo, affected households scored higher food insecurity than controls: 9.5 (0.5) vs. 5.4 (0.5) (P < 0.01) and higher diet diversity scores (DDS): 6.7 (0.2) vs. 6.2 (0.2) (P = 0.04). Type of housing also predicted food insecurity (P < 0.01) and DDS (P = 0.03). Like Bududa, households with insufficient water access scored higher food insecurity while those owning toilet scored higher DDS. Uniquely, only number of rooms was linked to a high likelihood of being food insecure (OR 1.60; 95% CI 1.19, 2.15; P < 0.05).Disaster, food security and diet were sensitive to housing, water and sanitation and were integral to an adequate standard of living of victims of this landslide.