Producido para IDRC por Baobab Productions Inc. | Productor: David Mowbray | Versión en inglés disponible en la Biblioteca Digital del IDRC: AQUAtox 2000 : the International Network on Water Toxicity; Réseau scolaire international sur la toxicité

7 páginas, 2 figuras, 1 tabla | [EN]Introduction: Obesity is well known to be related to the percentage of Total Body Water (TBW) and inflammation, but the relationship between TBW and inflammation remains still unconfirmed. Aim: To evaluate whether TBW is associated with inflammatory markers in obese children and adolescents. Material and methods: Thirty four obese children (7.0-10.9 yrs) and 49 obese adolescents (11.0-15.0 yrs) were recruited. Body mass index (BMI Z-score) and several serum biomarkers such as lipid profile, C-Reactive Protein (CRP), sE-selectin, sL-selectin, soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) and soluble Vascular Cell Adhesion Molecule-1 (s-VCAM-1) were determined. TBW was obtained by Bioelectrical measurements. Bilateral partial correlation test was used to analyze associations controlled by sex, age, and/or BMI Z-score. Results: A negative correlation was found between TBW and BMI Z-score in both children and adolescents (r -0.581,p < 0.001; r -0.368, p < 0.011, respectively) that remained in both sex, separately (r -0.540, p < 0.001; r -0.505, p < 0.001). In addition, TBW was also negatively correlated with CRP (r -0.438, p < 0.001) in both groups (r -0.560, p = 0.002; r -0.436, p = 0.007, respectively). When analyzed by sex, TBW was associated with CRP only in boys (r -0.588, p = 0.027; r -0.652, p = 0.005). TBW was negatively correlated with sE-selectin (r -0.236, p = 0.039) only in adolescents (r -0.320, p = 0.032). When analyzed by sex, TBW was associated with sE-selectin only in girls (r -0.432, p = 0.035). Conclusions: TBW may be considered as a marker not only of the hydration status, but also of the metabolic disorder in a low-grade inflammatory process such as obesity in children and adolescents. | [ES]:: Se conoce la relación de la obesidad con el porcentaje de agua corporal total (ACT) y con la inflamación,pero no se ha demostrado aún la posible asociación entre ACT y la inflamación. Objetivo: Evaluar si la ACT (como marcador de estado de hidratación) se asocia con marcadores de inflamación en niños y adolescentes obesos. | Peer reviewed

La investigación se enfoca en identificar el efecto de la cobertura en el acceso a agua clorada de las viviendas y la prevalencia de enfermedades diarreicas agudas en niños menores de 5 años en el distrito de Awajun, para lo cual se han analizado un total de 20 centros poblados del distrito. Se ha recopilado información de fuentes oficiales del periodo 2017 para proceder a realizar el procesamiento de datos y posterior análisis. A través de un análisis descriptivo de la información se ha logrado demostrar los niveles que toma cada variable a nivel de todo el distrito y a nivel de centros poblados, de igual forma se han realizado comparaciones entre ambas variables agrupando aquellos centros poblados que cuenta con acceso a agua clorada en contraste con aquellos que no lo cuenta. Como resultado se encontró que sólo 4 de cada 10 viviendas en el distrito de Awajun tienen acceso a agua clorada, existiendo una brecha de 1 421 viviendas, por su parte la prevalencia de enfermedades diarreicas agudas fue de aproximadamente 72 casos por cada 100 niños menores de 5 años del distrito de Awajun en el año 2017. El valor del coeficiente de correlación entre ambas variables fue de -0,24, con un valor de la significancia de la prueba de 0,31 lo cual indica que las variables no guardan una correlación o asociación estadísticamente significativa. Por lo tanto, incrementar el acceso a agua clorada a las viviendas de los centros poblados del distrito de Awajun, no se puede considerar una solución a dicho problema, ya que existen otros factores relacionados al grado de prevalencia de enfermedades diarreicas agudas. | This research is focused on identifying the effect of coverage on access to chlorinated water in homes and the prevalence of acute diarrheal diseases in children under 5 in the district of Awajun, for which a total of 20 town centers have been analyzed in the district. Information has been collected from official sources of the 2017 period to proceed with the data processing and subsequent analysis. Through a descriptive analysis of the information, it has been possible to demonstrate the levels taken by each variable at the level of the whole district and at the level of populated centers, in the same way comparisons have been made between both variables, grouping those population centers that have access to chlorinated water in contrast to those who do not. As a result, it was found that only 4 out of every 10 homes in the Awajun district have access to chlorinated water, with a gap of 1 421 homes, while the prevalence of acute diarrheal diseases was approximately 72 cases per 100 children under 5 years of the district of Awajun in the year 2017. The value of the coefficient of correlation between both variables was -0.24, with a value of the significance of the test of 0.31 which indicates that the variables do not correlate or statistically significant association. Therefore, increasing access to chlorinated water to housing in the population centers of the Awajun district cannot be considered a solution to this problem, since there are other factors related to the prevalence of acute diarrheal diseases.