The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin

Velev, R., Faculty of Veterinary Medicine, Skopje; Cupic, V., Faculty of Veterinary Medicine, Belgrade; Dobric, S., Military Medical Academy, Belgrade; Krleska-Veleva, N., Replekfarm AD Kozle, Skopje

The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin

2009

Velev, R., Faculty of Veterinary Medicine, Skopje (The Former Yugoslav Republic of Macedonia) | Cupic, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Dobric, S., Military Medical Academy, Belgrade (Serbia) | Krleska-Veleva, N., Replekfarm AD Kozle, Skopje (The Former Yugoslav Republic of Macedonia)

According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preventive or therapeutic. Our results suggest the potential therapeutic use of NO-donors in protection against NSAID-induced ulcerogenesis.

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Mots clés AGROVOC

digestive system diseases enfermedades del sistema digestivo indometacin indometacina maladie de l'appareil digestif nitric oxide oxyde nitrique rat rata rats

Informations bibliographiques

Editeur

Srpsko veterinarsko drustvo

Pagination

p. 405-406

D'autres materias

Oxido nitrico; Indometacine

Langue

anglais

ISBN

978-86-83115-13-6

Type

Conference

Source

[Veterinary medicine, life and health. Proceedings. The 8th congress of veterinarians of Serbia (with international participation)], Baltic, M.Z. (ed.-in-chief).- Beograd (Serbia): Srpsko veterinarsko drustvo, 2009. Kongres veterinara Srbije (sa medjunarodnim ucescem), 8., Beograd (Serbia), 15-19 Sep 2009.- 978-86-83115-13-6.- p. 405-406

Conférence

Kongres veterinara Srbije (sa medjunarodnim ucescem), 8., Beograd (Serbia), 15-19 Sep 2009

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The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin

2009

Mots clés AGROVOC

Informations bibliographiques