Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome
2022
Maria Alice Freitas Queiroz | Pablo Fabiano Moura das Neves | Sandra Souza Lima | Jeferson da Costa Lopes | Jeferson da Costa Lopes | Maria Karoliny da Silva Torres | Maria Karoliny da Silva Torres | Izaura Maria Vieira Cayres Vallinoto | Izaura Maria Vieira Cayres Vallinoto | Carlos David Araújo Bichara | Carlos David Araújo Bichara | Erika Ferreira dos Santos | Erika Ferreira dos Santos | Mioni Thieli Figueiredo Magalhães de Brito | Andréa Luciana Soares da Silva | Mauro de Meira Leite | Mauro de Meira Leite | Flávia Póvoa da Costa | Flávia Póvoa da Costa | Maria de Nazaré do Socorro de Almeida Viana | Maria de Nazaré do Socorro de Almeida Viana | Fabíola Brasil Barbosa Rodrigues | Fabíola Brasil Barbosa Rodrigues | Kevin Matheus Lima de Sarges | Kevin Matheus Lima de Sarges | Marcos Henrique Damasceno Cantanhede | Marcos Henrique Damasceno Cantanhede | Rosilene da Silva | Rosilene da Silva | Clea Nazaré Carneiro Bichara | Ana Virgínia Soares van den Berg | Adriana de Oliveira Lameira Veríssimo | Mayara da Silva Carvalho | Daniele Freitas Henriques | Carla Pinheiro dos Santos | Juliana Abreu Lima Nunes | Iran Barros Costa | Giselle Maria Rachid Viana | Francisca Regina Oliveira Carneiro | Vera Regina da Cunha Menezes Palacios | Juarez Antonio Simões Quaresma | Igor Brasil-Costa | Eduardo José Melo dos Santos | Luiz Fábio Magno Falcão | Antonio Carlos Rosário Vallinoto
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine synthesis. This study evaluated the impact of these factors on patients with clinical presentations of COVID-19 in a Brazilian cohort. A total of 317 patients diagnosed with COVID-19 were included; cases were distributed according to clinical status as severe (n=91), moderate (n=56) and mild (n=170). Of these patients, 92 had acute COVID-19 at sample collection, 90 had already recovered from COVID-19 without sequelae, and 135 had sequelae (long COVID syndrome). In the acute COVID-19 group, patients with the severe form had higher IL-6 levels (p=0.0260). In the post-COVID-19 group, there was no significant difference in cytokine levels between groups with different clinical conditions. In the acute COVID-19 group, younger patients had higher levels of TNF-α, and patients without comorbidities had higher levels of TNF-α, IL-4 and IL-2 (p<0.05). In contrast, patients over age 60 with comorbidities had higher levels of IL-6. In the post-COVID-19 group, subjects with long COVID-19 had higher levels of IL-17 and IL-2 (p<0.05), and subjects without sequelae had higher levels of IL-10, IL-6 and IL- 4 (p<0.05). Our results suggest that advanced age, comorbidities and elevated serum IL-6 levels are associated with severe COVID-19 and are good markers to differentiate severe from mild cases. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 and IL-10 appear to constitute a cytokine profile of long COVID-19, and these markers are potential targets for COVID-19 treatment and prevention strategies.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Directory of Open Access Journals
Découvrez la collection de ce fournisseur de données dans AGRIS
