Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
2018
Thibault Viennet | Michael M. Wördehoff | Boran Uluca | Chetan Poojari | Hamed Shaykhalishahi | Dieter Willbold | Birgit Strodel | Henrike Heise | Alexander K. Buell | Wolfgang Hoyer | Manuel Etzkorn
Thibault Viennet and colleagues gain structural insight into amyloid fibril formation from their innovative use of lipid bilayer nanodiscs. This study connects α-Synuclein membrane binding modes to its aggregation properties, furthering our understanding of the cause of neurodegerative diseases.
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