Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

Thibault Viennet; Michael M. Wördehoff; Boran Uluca; Chetan Poojari; Hamed Shaykhalishahi; Dieter Willbold; Birgit Strodel; Henrike Heise; Alexander K. Buell; Wolfgang Hoyer; Manuel Etzkorn

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

2018

Thibault Viennet and colleagues gain structural insight into amyloid fibril formation from their innovative use of lipid bilayer nanodiscs. This study connects α-Synuclein membrane binding modes to its aggregation properties, furthering our understanding of the cause of neurodegerative diseases.

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