Effect of dextran sulphate on IgG subclass of antibody in efferent popliteal lymph of sheep
1987
Kerlin, R.L. | Watson, D.L. (Commonwealth Scientific and Industrial Research Organization, Armidale (Australia). Div. of Animal Health)
IgG1 and IgG2 participation in anti-hapten, anti-carrier and immunoglobulin-containing cell (Ig-cc) responses was studied in sheep immunised with killed Staphylococcus aureus-Dinitrophenyl (DNP) conjugates. The antigen was given with and without the polyanionic adjuvant dextran sulphate (DXS). DXS markedly increased antibody responses to S. aureus-DNP in the popliteal lymph node, and strongly enhanced immunological memory. Any extrapolation of results from studies of immunomodulation by adjuvants should be undertaken cautiously, since the ratio of IgG2:IgG1 anti-DNP antibody in lymph draining lymph nodes stimulated with S. aureus-DNP alone did not differ significantly from the same ratio in lymph from animals given the antigen with DXS.
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