The interaction of phosphine with haemoglobin and erythrocytes

Chin, K.L.; Mai, X.; Meaklim, J.; Scollary, G.R.; Leaver, D.D.

The interaction of phosphine with haemoglobin and erythrocytes

1992

Chin, K.L. | Mai, X. | Meaklim, J. | Scollary, G.R. | Leaver, D.D.

Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.

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Mots clés AGROVOC

animals biotransformation blood erythrocytes erythrocytes hemoglobin hemolysis insecticides interactions metabolic detoxification metabolism pharmacokinetics phosphine rats rats rats spectral analysis spectrophotometry toxicity

Informations bibliographiques

Publié dans

Xenobiotica

Volume 22 Numéro 5 Pagination 599 - 607 ISSN 0049-8254

Editeur

American Chemical Society

D'autres materias

Phosphines; Oxyhemoglobin; Methemoglobin; Hemichrome; Phosphine biotransformation; Markers; Uptake; Hemoglobins; Sprague-dawley; Drug effects; Oxyhemoglobins

Langue

anglais

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-28

Format: MODS

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