The interaction of phosphine with haemoglobin and erythrocytes

Chin, K.L.; Mai, X.; Meaklim, J.; Scollary, G.R.; Leaver, D.D.

The interaction of phosphine with haemoglobin and erythrocytes

1992

Chin, K.L. | Mai, X. | Meaklim, J. | Scollary, G.R. | Leaver, D.D.

Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.

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Ключевые слова АГРОВОК

animals biotransformation blood erythrocytes erythrocytes hemoglobin hemolysis insecticides interactions metabolic detoxification metabolism pharmacokinetics phosphine rats rats rats spectral analysis spectrophotometry toxicity

Библиографическая информация

Опубликовано в

Xenobiotica

Том 22 Выпуск 5 Нумерация страниц 599 - 607 ISSN 0049-8254

Издатель

American Chemical Society

Другие темы

Phosphines; Oxyhemoglobin; Methemoglobin; Hemichrome; Phosphine biotransformation; Markers; Uptake; Hemoglobins; Sprague-dawley; Drug effects; Oxyhemoglobins

Язык

Английский

Тип

Text; Journal Article

В АГРИСе с: 2024-02-28

Формат: MODS

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