Efficient Route to Deuterated Aromatics by the Deamination of Anilines
2016
Burglova, Kristyna | Okorochenkov, Sergei | Hlaváč, Jan
One-step replacement of NH₂ groups in ring-substituted anilines by deuterium is reported. Approaches comprising both solid-phase and solution-phase syntheses can be used on a large variety of substrates. The method uses diazotization in a mixture of water and either dichloromethane or chloroform, which serve as a source of hydrogen. This protocol can be used as a general method for fast and easy incorporation of deuterium into an aromatic system using deuterated chloroform.
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