Efficient Route to Deuterated Aromatics by the Deamination of Anilines
2016
Burglova, Kristyna | Okorochenkov, Sergei | Hlaváč, Jan
One-step replacement of NH₂ groups in ring-substituted anilines by deuterium is reported. Approaches comprising both solid-phase and solution-phase syntheses can be used on a large variety of substrates. The method uses diazotization in a mixture of water and either dichloromethane or chloroform, which serve as a source of hydrogen. This protocol can be used as a general method for fast and easy incorporation of deuterium into an aromatic system using deuterated chloroform.
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书目信息
Organic letters
卷
18
期
14
页码
3342
- 3345
ISSN
1523-7052
出版者
American Chemical Society
其它主题
Methylene chloride
语言
英语
类型
Journal Article; Text
2024-02-28
MODS