Diterpenoid compounds from Vitex agnus-castus
2013
Pal, Mahesh | Li, Sheng-Hong | Tewari, Shri Krishan | Sun, Han-Dong
A new diterpenoid alkaloid having an α,β-unsaturated γ-lactam moiety, 9α-hydroxy-13(14)-labden-16,15-amide (1), together with five known ones, was isolated from the fruits of Vitex angus-castus. The structure of 1 was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.The cytotoxicity of each compound was evaluated against human chronic myelogenous leukemia (K562) cell lines. Compound 1 was found to be the most potent with IC₅₀ value of 0.70 μg/mL.
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