In Vitro studies of fatty acid metabolism in vitamin B6 deficient rats
1979
Dussault, Pierre E. | Lepage, Marius
Extract: The oxidation of palmitate, linoleate, and arachidonate as well as their incorporation into lipids was investigated in vitamin B6 deficient rats using liver slices and isolated mitochondria. In experiments on fatty acid oxidation in liver slices, a decrease was observed in the production of 14CO2 from radioactive palmitate and linoleate, but not from arachidonate. Major changes occurred in metabolism of palmitate and linoleate. The decrease in the arachidonate content previously observed in rat tissues could not be explained by alteration in the metabolism of this fatty acid.
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