Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters
2015
Yu, Kunru | Liu, Xiaohua | Lin, Xiaobin | Lin, Lili | Feng, Xiaoming
A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis.
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