Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters

Yu, Kunru; Liu, Xiaohua; Lin, Xiaobin; Lin, Lili; Feng, Xiaoming

Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters

2015

Yu, Kunru | Liu, Xiaohua | Lin, Xiaobin | Lin, Lili | Feng, Xiaoming

A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis.

显示更多 [+]