Epoxytwinol A, a novel unique angiogenesis inhibitor with C₂ symmetry, produced by a fungus
2005
Kakeya, Hideaki | Onose, Rie | Koshino, Hiroyuki | Osada, Hiroyuki
We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C₂ symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED₁₀₀ = 2.6 µM).
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