Epoxytwinol A, a novel unique angiogenesis inhibitor with C₂ symmetry, produced by a fungus

Kakeya, Hideaki; Onose, Rie; Koshino, Hiroyuki; Osada, Hiroyuki

Epoxytwinol A, a novel unique angiogenesis inhibitor with C₂ symmetry, produced by a fungus

2005

Kakeya, Hideaki | Onose, Rie | Koshino, Hiroyuki | Osada, Hiroyuki

We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C₂ symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED₁₀₀ = 2.6 µM).

显示更多 [+]