Lyl-1 regulates primitive macrophages and microglia development
2021
Shoutang Wang | Deshan Ren | Brahim Arkoun | Anna-Lila Kaushik | Gabriel Matherat | Yann Lécluse | Dominik Filipp | William Vainchenker | Hana Raslova | Isabelle Plo | Isabelle Godin
Wang et al. use transcriptomic analysis to show that disruption of the transcription factor Lyl-1 in primitive macrophage progenitors results in defective differentiation that impacts on embryonic patterning and neurodevelopment. They also show that Lyl-1 disruption leads to a reduction in mature microglia, thus revealing its role in macrophage and microglial development
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