Lyl-1 regulates primitive macrophages and microglia development

Shoutang Wang; Deshan Ren; Brahim Arkoun; Anna-Lila Kaushik; Gabriel Matherat; Yann Lécluse; Dominik Filipp; William Vainchenker; Hana Raslova; Isabelle Plo; Isabelle Godin

Lyl-1 regulates primitive macrophages and microglia development

2021

Wang et al. use transcriptomic analysis to show that disruption of the transcription factor Lyl-1 in primitive macrophage progenitors results in defective differentiation that impacts on embryonic patterning and neurodevelopment. They also show that Lyl-1 disruption leads to a reduction in mature microglia, thus revealing its role in macrophage and microglial development

显示更多 [+]