Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device
2021
Jose Montoya Mira | Ajay A. Sapre | Brett S. Walker | Jesus Bueno Alvarez | Kyle T. Gustafson | Eugene Tu | Jared M. Fischer | Melissa H. Wong | Sadik Esener | Yu-Jui Chiu
Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then applied it to clinical samples for clinically relevant mutation analyses.
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