Toxicological characterisation of furan fatty acids (FFAs) which are oxidative metabolites of the food ingredient conjugated linoleic acid (CLA) using proteomic techniques
2008
Lengler,I. | Brandenburger,L. | Buhrke,T. | Lampen,A.
allemand. Caco-2 cells resorb and/or metabolize 9,11-FFA.9,11-FFA is not genotoxic.9,11-FFA and 8,10-FFA are cytotoxic, inhibit cell proliferation and induce apoptosis only atconcentrations two orders of magnitude higher than 10E,12Z-CLA.In Caco-2 cells only the amount of TPI was increased at least twofold after exposure to 1 mM9,11-FFA-> According to the in vitro results we conclude that the toxicity of FFAs is probablynegligible for the risk assessment of CLA.
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