The results of Pasteurella allocation from fur animals on the basis of studying of their cultural-morphological, biochemical properties and definition of a specific accessory are given. As a result of carrying out of bacteriological research of the pathological material received from fur animals, pure cultures have been allocated. On the basis of cultural-morphological and biochemical properties these cultures are carried to Pasteurella multocida. At serotyping these cultures Pasteurella multocida are carried to serovariants A, B and D. For selection the most important in the epizootic relation serovariants A and B Pasteurella multocida have been selected. Selected strains of serovariants A and B Pasteurella multocida had stable properties for everyone serovariant Pasteurella, that has given the basis to passport them in a collection of microorganisms to The S.N.Vyshelesskij Institute of Experimental Veterinary Medicine and a demand tax in the National centre of intellectual property at Ministerial council of Belarus on patents | Приводятся результаты выделения от пушных зверей пастерелл на основании изучения их культурально-морфологических, биохимических свойств и определение серовариантной принадлежности. В результате проведения бактериологических исследований патологического материала, полученного от пушных зверей, были выделены чистые культуры на основании культурально-морфологических и биохимических свойств и отнесены к Pasteurella multocida. При серотипизации установленные культуры Pasteurella multocida отнесены к серовариантам А, В и D. Для проведения селекции были отобраны наиболее важные в эпизоотическом отношении серовариан-ты А и В Pasteurella multocida. Селекционированные штаммы серовариантов А и В Pasteurella multocida имели стабильные свойства для каждого сероварианта пастерелл, что дало основание паспортизировать их в коллекции микроорганизмов Инстита экспериментальной ветеринарии им. С.Н. Вышелесского и подать заявки в Национальный центр интеллектуальной собственности при Совете Министров Республики Беларусь на патенты

There was realized the estimation of influence of application of biometals in a ration of chickens-broilers of different age on the content in their blood macro-and microelements. It is possible to make the conclusion, that in blood of chickens-broilers the tendency to decrease with the years concentration of calcium and magnesium, to increase of level of phosphorus, zinc and copper, and also increase the content of cobalt with 23-day age to 33-day and its insignificant decrease by 45 day of a life of chickens takes place. At the same time application in a ration of chickens-broilers of biometals sodium-ferrum-ethylenediaminetetraacetate (Na-Fe-etda) from calculation of 2,5 mg/kg, sodium-zinc-ethylenediaminetetraacetate (Na-Zn-etda) - 5,5 mg/kg, sodium-cobalt- ethylenediaminetetraacetate (Na-Co-etda) - 5,5 mg/kg and sodium-cuprum-ethylenediaminetetraacetate (Na-Cu-etda) - 3,5 mg/kg of body weight in the basic weight led to small increase of level macro- and microelements in blood of chickens-broilers and did not render negative influence on safety and a gain of body weight of chickens in trial group. Data on concentration of macro- and microelements in blood and a body weight gain of chickens-broilers are presented. | Целью работы является оценка влияния применения биометаллов в рационе цыплят-бройлеров разного возраста на содержание в их крови макро- и микроэлементов. Можно сделать заключение, что в крови цыплят-бройлеров имеет место тенденция к снижению с возрастом концентрации кальция и магния, повышению уровня фосфора, цинка и меди, а также увеличению содержание кобальта с 23-дненвного возраста к 33-дневному и незначительному снижению его к 45-му дню жизни цыплят. В то же время применение в рационе цыплят-бройлеров биометаллов натрий-ферум-этилендиаминтетраацетат (Na-Fe-etda) из расчета 2,5 мг/кг, натрий-цинк-этилендиаминтетраацетат (Na-Zn-etda) - 5,5 мг/кг, натрий-кобальт-этилендиаминтетраацетат (Na-Co-etda-) - 5,5 мг/кг и натрий-купрум-этилендиаминтетраацетат (Na-Cu-etda) - 3,5 мг/кг живой массы в основной своей массе приводило к небольшому повышению уровня макро- и микроэлементов в крови цыплят-бройлеров и не оказывало негативного воздействия на сохранность и прирост живой массы цыплят опытной группы. Представлены данные по концентрации макро- и микроэлементов в крови и прирост живой массы цыплят-бройлеров.

In the conditions of the Republic of Belarus there was studied the influence of electroactive solutions of anolyte neutral, catholyte alkaline and hypochlorite sodium on microbial flora of a gastro enteric path of calves and sheep. In course the realized research it was stated that more expressed action of anolyte neutral and hypochlorite sodium on beneficial microflora of animal intestines (namely, the decrease in quantity of some indexes) can probably be explained by an expressed antimicrobic action of the analyzed solutions. However, the quantitative changes occurring in composition of microbial flora were not so great and cannot cause radical changes of a microbial landscape of gastro-intestinal tract. Less expressed influence on microbial flora of intestines of calves and sheep rendered the solution of alkaline catholyte. Taking into consideration the expressed regenerative properties of the studied electroactive solution, it was possible to assume, that according to the mode of action of the preparation, its application will promote the increasing of protective forces of an organism without causing any radical changes of a microbial landscape of intestines of animals. The problem of influence of electroactive solutions on a microbial landscape of a gastro enteric tract of animals demands the further studying, however at the given stage it is possible to make a conclusion, that the quantitative changes of the microbial flora which were caused by application of the analyzed solutions, proved to be less fatal and did not render sharp negative influence on a microbial landscape as a whole. Taking into consideration data of the realized research it is possible to make a conclusion on possibility of application of the electro activated solutions of anolyte neutral, catholyte alkaline and hypochlorite sodium for treatment of gastro enteric tract diseases of agricultural animals.

There was estimated the indogenic intoxication development in animal, experimentally affected with larval cestodoses and its influence on meat quality. In the tabular form the indicators of farm animal parasitizing with larval cestodoses are presented; development indicators of endogenic intoxications of sheep parasitized with cysticercus; development indicators of endogenic intoxications of the rats parasitized with echinococcus larvacyst; dynamics of hematological indicators at sheep, experimentally infected with eggs Т Hydatigena; dynamics of hematological indicators of the laboratory rats experimentally infected with eggs Е granulosus; organoleptic meat characteristics of healthy sheep and sheep which affected with С Tenuicollis; biological value of sheep meat. As a result of the spent research it is revealed, that parasitizing of larval cestodoses at farm animals is accompanied by development of endogenic intoxications and as consequence considerably reduces quality of meat production. | Цель работы заключалась в оценке развития эндогенной интоксикации у животных, экспериментально инвазированных яйцами тениид, и ее влияния на качество получаемой мясной продукции. В табличной форме представлены показатели пораженности сельскохозяйственных животных личиночными формами цестод; показатели развития эндогенной интоксикации овец, пораженных цистицерками тенуикольными; показатели развития эндогенной интоксикации крыс, пораженных ларвоцистами эхинококка; динамика гематологических показателей у овец, экспериментально инвазированных яйцами Т. Hydatigena; динамика гематологических показателей лабораторных крыс, экспериментально зараженных яйцами Е. granulosus; органолептические показатели мяса овец здоровых и пораженных С. Tenuicollis; биологическая ценность мяса овец. В результате проведенных исследований выявлено, что паразитирование личиночных форм цестод у сельскохозяйственных животных сопровождается развитием эндогенной интоксикации и как следствие значительно снижает качество мясной продукции.

The immune status of chickens, pigs and calves depends on the content of protective factors in incubatory egg, mother colostrum and timely transfer to their posterity. At young growth in postnatal ontogenesis it is allocated three age immune deficiencies. The first is connected with untimely receipt transovarian and colostoral factors of the protection, the second is caused by an expenditure of passively transferred protective factors of protection and immaturity of own immune system. The third age immune deficiency arises at sharp transfer of young growth into new type of feeding and concerns, first of all, disorders of local protection of a digestive path. Timely application the probiotic enterobifidin, baktril-2, bifidoflorin, developed by Vitebsk State Academy of Veterinary Medicine together with Institute of microbiology of the National Academy of Sciences of Belarus, microbic polysaccharides salmopul and vistimulin, received together with Vitebsk biofactory, and also diamiksan allows to prevent development of immune deficiencies and on their background gastroenteric and respiratory diseases of young growth, to stimulate animal growth and to improve quality of meat production, decrease economic efficiency and ecological safety, considerably allows to reduce application of antimicrobic preparations (antibiotics, Sulfanilamidum, Nitrofuranums, etc.) | Иммунный статус цыплят, поросят и телят зависит от содержания защитных факторов в инкубационном яйце, молозиве матерей и своевременной передаче их потомству. У молодняка в постнатальном онтогенезе выделяется три возрастных иммунных дефицита. Первый связан с несвоевременным поступлением трансовариальных и колостральных факторов защиты, второй обусловлен расходованием пассивно перенесенных защитных факторов защиты и незрелостью собственной иммунной системы. Третий возрастной иммунный дефицит возникает при резком переводе молодняка на новый тип кормления и касается, прежде всего, нарушения местной защиты пищеварительного тракта. Своевременное применение пробиотиков энтеробифидина, бактрила-2, бифидофлорина, разработанных Витебской государственной академией ветеринарной медицины совместно с Институтом микробиологии НАН Беларуси, сальмопула и витстимулина, совместно полученных с Витебской биофабрикой микробных полисахаридов, а также диамиксана позволяет профилактировать развитие иммунных дефицитов и возникающих на их фоне желудочно-кишечных и респираторных болезней молодняка, стимулировать рост животных и улучшать качество мясной продукции, повышать экономическую эффективность и экологическую безопасность, значительно сократить применение противомикробных препаратов (антибиотиков, сульфаниламидов, нитрофуранов и др.)

In the conditions of the Republic of Belarus by an example model of a purulent wound at rats there was realized an experimental study of pharmacological activity of a medical remedy PhytoMP (containing active substances of Macleaya microcarpa (Maxim.) Fedde of Papaveraceae family; and Plantago major L. of Plantaginaceae family) in the form of powder. It was established, that the intensity wound-healthing effect depended on a ratio of the components plume poppy / greater plantain 1 + 1:1, 2:1, 1:2. Studying of the remedy safety showed that PhytoMP in the maximal dozes was not toxic for animals after a single unitary intragastric administration in dose of 50000 mg/kg to mice and in dose of 20833 mg/kg to rats. The mentioned above indexes surpassed the recommended for human dose after application tonsilles (1,428 mg/kg) in 35014 and 14589 times, and also the recommended for human doses for application at a wound with size of 2x2 square cm (11,424 mg/kg) - in 4377 and 1824 times, respectively.

Factors which increased milk productivity (age and continuance of service period) were studied in the conditions of an educational establishment of the Republic of Belarus by an example of cows of black-and-white breed. Dynamics of growth of milk productivity in course of 8 research years was presented. Analysis of interrelation between cow productivity and cow age was given. Mathematical calculation of relations between cow productivity indexes (milk yield, fat content, butter fat) and service period duration was given. Research results showed that increasing of an average term of economic use of cows and decreasing of duration of service period up to 90 days made it possible to increase dairy effiiemcy and herd reproduction, as well as obtain higher economic efficiency

Sodium hypochlorite solution is an effective means in control of noncontagious aetiology diseases, accompanied by development of endogen intoxications. The detoxification action of sodium hypochlorite is that in the body there is no becomes free active oxygen, oxidizing there toxic and ballast substances as bilirubin, urea, ammonia, uric acid, creatinine, cholesterol, carbonic oxide, acetone, acetone acetate, ethanol, methanol, barbiturates, etc. The detoxification action of sodium hypochlorite is shown in neutralization of exotoxins and endotoxins of pathogenic microorganisms as it represents a compound of the small molecular mass and the small structural size. In this connection it freely gets through membranes of cells and oxidizes the toxins containing not only in blood, but also in cells. From this follows, that sodium hypochlorite models not only oxidizing function of cytochrome Р-450 of liver, but also phagocytal function of neutrophilic leucocyte. It leads to inactivation of large toxic molecular compounds both on a surface of uniform elements, and in blood plasma while effective methods reduce intoxication at the expense of removal of the average molecules circulating in plasma