In the conditions of the Republic of Belarus there were studied the anthelminthic properties of preparative forms of elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts). Research results showed that the analyzed preparative forms in the administrated doses possesed high therapeutic efficiency against strongyloidosis and strongylatosis of gastroenteric path of sheep. Thus, according to results of research it was established, that the highest therapeutic effect rendered herbal infusion of elecampane in a dose of 6 ml/kg live weight once a day three days continuously; and the antiparasitic efficiency was 60%. Application of elecampane tincture in a dose of 1 ml/kg live weight once and 0,5 ml/kg of live weight twice rendered the 100% therapeutic effect. Administration of a liquid extract of elecampane in a dose of 0,2 ml/kg live of weight once and 0,1 ml/kg of live weight twice rendered 100% therapeutic effect. Application of elecampane dry extract in a dose of 30 mg/kg of live weight once and 25 mg/kg of live weight twice rendered 100% therapeutic effect.

Studying of topical-product-induced irritation properties of pharmaceutical forms elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts) on skin integuments and conjunctiva of experimental animals (Guinea pigs (Cavia porcellus), rabbits (Oryctolagus), sheep and piglets). Research results showed that the preparative forms of elecampane had poorly expressed irritating properties after application on the skin of animals, as well as weak irritating action with the exception of the native forms of tincture and liquid extract of eye conjunctiva, that proved their total low toxic effect. Topical-product-induced irritation effect of herbal infusion (1:10), tincture and liquid extract in constitution (40 % concentration) and suspension of dry extract in strength of 10%, 15%, and 20% after the single application on skin could be referred to the I class – absence of irritating action. Topical-product-induced irritation effect of herbal infusion and liquid extract in native form (70% concentration) could be referred to the II class – light irritating action. Irritating activity of herbal infusion of eye conjunctiva was evaluated as light, as it was insignificant and short. Irritating action of suspended matter of dry extract in strength of 10%, 15%, and 20% was estimated as a limited one, which disappeared in 24 hours. Irritating action of tincture and liquid extract in constitution (40 % concentration) was evaluated as a high-grade one, which did not disappear in 24 hours. Irritating action of tincture and liquid extract in native form (70 % concentration) was evaluated as a pronounced one, which did not disappear for than 24 hours

Investigation of acute and subacute toxicity of formulations of elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts) by the example of experimental white mice of both sexes ( body weight - 18-20 g) and white rats (body weight - 180-200 g) was realized in the conditions of the Republic of Belarus. In course of studies there were analyzed behavior (excitation or depression), physical activity, habitus, appetite, degree of reaction revelation to exogenous irritants, presence of shivering, cramps, paresis, comatose state, time and character of intoxication, dates of animal death). Results of the toxicological experiments showed that the developed preparative forms of elecampane could be referred to the substance hazard category 4, i.e. low-hazardous substances (lethal dose (LD) sub(50) more than 5000 mg/kg live weight). Median lethal dose of tincture was 14043 mg/kg for mice and 12684 mg/kg for rats. Median lethal dose of liquid extract was 13230 mg/kg for mice and 12285 mg/kg for rats

Results of studying the local of irritating properties of preparative forms of marsh cinquefoil (Comarum palustre) which were intended for treatment of parasitic of diseases of animals, namely, strongylatosis of gastro-intestinal tract of sheep and calves realized in the conditions of the Republic of Belarus were presented. Preparative forms of Comarum palustre (liquor, tincture, liquid extract and powder) had poorly expressed irritating properties after application into skin of animals and weak irritating action, excluding native forms of tincture and liquid extract on mucous coat eye, that confirms their low toxicity action as a whole on organism of animals.

In the conditions of the Republic of Belarus there was studied the influence of herbal infusion, tincture, liquid and dry extracts of elecampane (Inula helenium) on morphological and biochemical indexes of pig blood. In course of the study it was established, that preparative forms of elecampane stimulated the formation of blood corpuscle, and also increased of the hemoglobin level in blood of pigs. Administration of elecampane preparations did not cause any authentic changes in blood leukogram of swine; all indicators were within normal limits. Elecampane preparations did not cause changes on the part of biochemical blood indexes of and did not influence the activity of enzymes. Research results showed that herbal infusion, tincture, liquid and dry extracts of elecampane did not render negative influence on swine.

In the conditions of the Republic of Belarus there was studied the propagation, botanical characteristic, chemical composition and pharmacological properties of marsh cinquefoil (Comarum palustre) and its application in the veterinary practice against strongylatosis (Strongylata) of gastrointestinal system of cattle young stock. Reserch results showed that the perennial herbage plant marsh cinquefoil from Rosales (Rosaceae) family possessed different therapeutic properties: antipyretic agent; styptic agent; diuretic agent; bonding agent; wound healing substance; tonic agent; promotoring agent. Research results showed that the preparative forms (broth; liqueur; liquid juice; powder) of marsh cinquefoil possessed an active agent proanthocyanidin, a condensed tanning substance which were included into composition of a polyphenolic complex and proved to be efficient for treatment of cattle young stock strongylatosis.

In the conditions of the Republic of Belarus by an example model of a purulent wound at rats there was realized an experimental study of pharmacological activity of a medical remedy PhytoMP (containing active substances of Macleaya microcarpa (Maxim.) Fedde of Papaveraceae family; and Plantago major L. of Plantaginaceae family) in the form of powder. It was established, that the intensity wound-healthing effect depended on a ratio of the components plume poppy / greater plantain 1 + 1:1, 2:1, 1:2. Studying of the remedy safety showed that PhytoMP in the maximal dozes was not toxic for animals after a single unitary intragastric administration in dose of 50000 mg/kg to mice and in dose of 20833 mg/kg to rats. The mentioned above indexes surpassed the recommended for human dose after application tonsilles (1,428 mg/kg) in 35014 and 14589 times, and also the recommended for human doses for application at a wound with size of 2x2 square cm (11,424 mg/kg) - in 4377 and 1824 times, respectively.

Results of treatment and preventive maintenance of mastitis of lactating nonmilking cows and heifers with the help of a new probiotic preparation Lactosan realized in the conditions of the Republic of Belarus were presented. The developed new environmentally safe antimastitis preparation Lactosan contained lactic acid bacteria Lactobacillus plantarum and Lactobacillus acidophilus in amount not less than10E7 CFU/cm3 did not render irritating action on mucous membranes, did not cause a sensitization and according to its toxicity indexes could be concern to low-hazardous substances. Therapeutic effectiveness of Lactosan against subclinical mastitis was 84,2-94,1%; in case of serous and catarrhal mastitis – 63,2-68,4%; and after two therapy regimen – 79,0-84,2%.

Due to Herbal medicine it is possible to use cheap and ecological clean preparation. Studied medicinal forms of wormwood bitter (the wormwood bitter extract, fluid extract, Artemizitan) in therapeutic dose stimulate the factors of natural resistance beside animals. Results of studying of lysozyme activity in blood serum have shown that preparations of wormwood bitter have caused authentic increase of this indicator in comparison with control animals, both in pigs, and at sheep. Bactericidal activity of blood serum was authentically more than in control group, both at pigs, and at sheep after introduction of infusion of wormwood bitter. Studying of influence of wormwood bitter on phagocytosis indicators has shown, that all medicinal forms of plant have made stimulating impact on phagocytal activity of neutrophils and phagocytal number both in experiences on pigs, and on sheep. Artemitizan has caused authentic increase and phagocytal index. Thus, the research will be coordinated with literary data, that preparations of wormwood bitter make stimulating impact on indicators of natural resistance of animal blood | Благодаря фитотерапии возможно использование дешевых и экологически чистых препаратов. Изученные лекарственные формы полыни горькой (настой полыни горькой, жидкий экстракт полыни горькой, артемизитан) в терапевтических дозах стимулируют показатели естественной резистентности у животных. Результаты изучения лизоцимной активности в сыворотке крови показали, что препараты полыни горькой вызвали достоверное повышение этого показателя по сравнению с контрольными животными, как у свиней, так и у овец. Бактерицидная активность сыворотки крови была достоверно больше, чем в контрольной группе, как у свиней, так и у овец после введения настоя полыни горькой. Изучение влияния полыни горькой на показатели фагоцитоза показало, что все лекарственные формы растения оказали стимулирующее влияние на фагоцитарную активность нейтрофилов и фагоцитарное число как в опытах на свиньях, так и на овцах. Артемизитан вызвал достоверное повышение и фагоцитарного индекса. Таким образом, наши исследования согласуются с литературными данными, что препараты полыни горькой оказывают стимулирующее влияние на показатели естественной резистентности крови животных