Melatonin, the principal hormone of the vertebral pineal gland, participates in the regulation of cardiovascular system in vitro and in vivo. Lithium inhibits both inositol polyphosphate phosphatase (IPPase) and inositol monophosphatase (IMPase), which are involved in a wide range of signal transduction pathways. The aim of the present study was to assess the effect of lithium on endothelial-dependent relaxation to melatonin and on the melatonin-induced inhibition of contraction by phenylephrine (PE) in isolated rat aorta. Melatonin induced a concentration-dependent relaxation in PE-precontracted in endothelium-intact (+E) aortic rings.

Influence of inorganic and organic salts of lithium on activity of amplifiers and concentration of metabolites in plasma of chicken blood in the process of vaccination against infectious bursal disease was studied in the conditions of the Republic of Belarus. After administration of lithium of citrate, sulfate and succinate there were noted the metabolic disorders. Research results testified that a dry live-viral vaccine on the basis of a strain KMIEhV-61 did not render essential influence on biochemical indicators of blood plasma. At the same time, immunization of chickens against application of salts of lithium (carbonate, sulphate, citrate, succinate) caused to authentic decrease in activity of alanine aminotransferase that testified to function oppression of hepatocytes. Application of lithium of citrate, sulfate and succinate made it possible to considerably increase the concentration of uric acid that was connected, apparently, with infringement of secretory function of kidneys. Metabolic disorders were observed in various terms of research - at 3, 7 and 14 days after vaccine administration. | Изучено влияние неорганических и органических солей лития на активность индикаторных ферментов и концентрацию метаболитов в плазме крови цыплят при вакцинации против инфекционной бурсальной болезни (ИББ). Выявлены метаболические нарушения при использовании лития цитрата, сульфата и сукцината. Полученные результаты исследований свидетельствуют о том, что сухая живая вирус-вакцина из штамма КМИЭВ-61 не оказывает существенного влияния на биохимические показатели плазмы крови. В то же время иммунизация цыплят на фоне применения солей лития (карбонат, сульфат, цитрат, сукцинат) приводит к достоверному снижению активности АлТ, что свидетельствует об угнетении функции гепатоцитов. Применение лития цитрата, сульфата и сукцината способствует также достоверному повышению концентрации мочевой кислоты, что связано, по-видимому, с нарушением выделительной функции почек. Метаболические нарушения наблюдаются в различные сроки исследований - на 3, 7 и 14 дни после введения вакцины.

In the conditions of the Republic of Belarus there was determined the influence of different rates of lithium addition into mixed fodders for sows feeding on hematological indexes and their reproductive qualities. In course of the study there was analyzed the dynamics of body weight of sows over the reproductive period; indexes of productivity of sows (number of born piglets; weight of 1 piglet; litter weight; weight of weanling piglets; number of weanling piglets; etc.); hematological indexes of sows; state of humoral factors of immunity of sows. Research results showed that in case of lithium application in diets of sows there was stated an improvement of hematological indexes and immunity functions and resistance. The optimal level of lithium in rations was 15 milligram per 1 kilogram of dry matter of a diet. This dose essentially promoted the increasing of reproductive performance, piglets weight and milking capacity of sows as well as better viability of piglets.