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Efficacy and clinical trials of Salenvac-T, bivalent killed vaccine containing Salmonella Enteritidis and Salmonella Typhimurium
2013
Cho Y, Kangwon National University, Chuncheon, Republic of Korea | Kang ZW, Kangwon National University, Chuncheon, Republic of Korea | Kang KS, Dongducheon Bayel Animal Clinic, Dongducheon, Republic of Korea | Jeong S, Intervet (MSD AH) Korea, Republic of Korea | Yoon HJ, Kangwon Veterinary Clinic, Wonju, Republic of Korea | Suh S, Intervet (MSD AH) Korea, Republic of Korea | Hahn TW, Kangwon National University, Chuncheon, Republic of Korea
Commercial bivalent killed Salmonella vaccine Salenvac-T has been used in several countries in order to prevent salmonellosis with Salmonella enterica serovars Enteritidis (SE) and Typhimurium (ST) in poultry. However, this vaccine has not been used in poultry farms in South Korea. In this study, we evaluated the efficacy of Salenvac- T vaccine to protect against the challenge of virulent SE and ST, and the effect of the vaccine on egg production and mortality in layer hens. The colonization of liver, spleen and cecum with challenged SE and ST was reduced in vaccinated chickens compared with that of unvaccinated control group. The twice vaccination with Salenvac-T induced elevated antibody responses against both SE and ST detected by enzyme-linked immunosorbent assay (ELISA). The higher average hen-day production was observed in the vaccinated layer hens than in the unvaccinated layer hens without significance. The average mortality was lower in the vaccinated layer hens during the experiment period. The antibody responses to both SE and ST were persistently detected in the vaccinated layers. In summary, vaccination with Salenvac-T reduces colonization of internal organs and induces good antibody responses, thereby results in higher performance and lower egg contamination with SE and ST in layer hens.
Afficher plus [+] Moins [-]Comparative evaluation of the murine immune responses to Salmonella enterica serovars Enteritidis, Gallinarum and Typhimurium infection
2013
Kim, K., Kangwon National University, Chuncheon, Republic of Korea | Kim, D., Kangwon National University, Chuncheon, Republic of Korea | Sun, J., Kangwon National University, Chuncheon, Republic of Korea | Park, S., Kangwon National University, Chuncheon, Republic of Korea | Cho, Y., Kangwon National University, Chuncheon, Republic of Korea | Ko, H.J., Kangwon National University, Chuncheon, Republic of Korea | Joo, H.G., Jeju National University, Jeju, Republic of Korea | Hahn, T.W., Kangwon National University, Chuncheon, Republic of Korea
The study was carried out to evaluate and compare the immune responses in mice experimentally infected with either wild-type or isogenic mutants of Salmonella enterica serovars Enteritidis (SE), Salmonella Typhimurium (ST) and Gallinarum (SG). The mutant strains were constructed by allelic replacement of some virulence-associated genes in the wild-type strains. Seven-week-old female BALB/c mice were orally or intraperitoneally inoculated by injecting bacterial suspension. To evaluate the immune responses, enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot (ELISPOT) assay were conducted with serum and fecal samples. As a result, the mice group infected orally with the SE mutant strain showed the highest level of specific IgA-secreting splenocytes, compared to the other groups. The peritoneally injected groups showed the greater levels of IgG1 than the orally injected groups, which was in a good agreement with the previous studies. In addition, the mutant infected groups had the similar secretion levels of antibodies with the wild-type infected groups. These results demonstrated that the SE mutant strain elicited humoral immune response as much as wild-type, implying that it can be useful as a delivery vehicle as well as a candidate of a live attenuated vaccine.
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