Glutathione peroxidase activity and erythrocyte lipid peroxidation as indices of selenium and vitamin E status in young pigs [mulberry heart disease, dietetic hepatosis, nutritional muscular dystrophy]
1979
Jensen, P.T. (Statens Veterinaere Serumlaboratorium, Copenhagen (Denmark)) | Danielsen, V. | Nielsen, H.E.
A randomized, blocked 2('3) factorial experiment was conducted with 48 pigs from sows fed a diet low in selenium and vitamin E. From 3 to 12 weeks of age the piglets were kept in single pens and fed a basic diet consisting mostly of barley, dried skim milk, soybean meal and dried yeast, and containing 55 mu-g selenium and 3 mg vitamin E per kg. The treatment factors (i.e. feed supplements) were 2 levels of Se (nil, 60 mu-g/kg), 2 levels of vitamin E (nil, 50 mg/kg), and 2 levels of the feed antioxidant ethoxyquin (nil, 150 mg/kg). Blood samples, collected at termination of the experiment, were examined for gluthathion peroxidase activity (GSH-Px) and resistance against erythrocyte lipid peroxidation (ELP) to evalute Se and vitamin E status, respectively. Analysis of variance showed the GSH-Px activity to be litter-dependent (P 0.001) and influenced by selenium supplementation (P 0.001) but not by the other supplements or by interactions between supplements. Resistance against ELP was influenced only by vitamin E supplementation (P 0.001). GSH-Px and ELP thus seem to be valuable and simple methods for evaluating, respectively, Se status and vitamin E status in growing pigs.
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