Studies on gentamicin-induced nephrotoxicity in rats

Cho, I.S.; Kim, T.J.; Yoon, H.J. . Dept. of Veterinary Medicine

Studies on gentamicin-induced nephrotoxicity in rats

1986

Cho, I.S. | Kim, T.J. | Yoon, H.J. (Konkuk Univ., Seoul (Korea R.). Dept. of Veterinary Medicine)

Sprague-Dawley rats received subcutaneous injections of gentamicin sulfate, 50 and 100mg/kg for 3, 7 and 10 days. The hematological and blood chemical values were determined. Kidneys were examined histologically and ultrastructurally. The serum values of aspartate transaminase, blood urea nitrogen and creatinine in the rats administered gentamicin, 50 and 100mg/kg/day were significantly increased than those in the control. The ratio of kidney weight to body weight was significantly increased in the rats injected gentamicin, 100mg/kg for 10 days than those in the control

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