Immunobiological studies on mice treated with chemical carcinogen, 3-methylcholanthrene, 2; rosette formation and natural killing (NK) activity of splenic lymphocytes

Song, H.J.; Kim, S.H.; Kim, J.M.

Immunobiological studies on mice treated with chemical carcinogen, 3-methylcholanthrene, 2; rosette formation and natural killing (NK) activity of splenic lymphocytes

1986

Song, H.J. | Kim, S.H. | Kim, J.M. (Chonbuk National Univ., Chonju (Korea R.))

The present study was undertaken to evaluate rosette formation and NK activity of splenic lymphocytes in 3-methylcholanthrene (MCA) treated mice. Mice were sensitized iv with 0.1ml of 1% sheep red blood cell (SRBC) suspension were treated with a single ip injection of olive oil alone or with different doses of MCA in oil at various time before or after sensitization, and were challenged at 4 days after SRBC. Rosette formation and NK activity of splenic lymphocytes were measured at 24 hrs after challenge

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