Effect of dexamethasone on porcine enterovirus infections in pigs
1986
Chang, S.M. | Lee, C.S. (Kyongbuk National Univ., Taegu (Korea R.). Dept. of Veterinary Medicine)
Four colostrum-deprived, 1 day old pigs were orally infected with the porcine enterovirus isolated in Korea. Two of the pigs were treated with dexamethasone (5mg/kg/day) for 3 days. The others as control were infected with porcine enterovirus only. The treated, infected pigs developed ataxia at 3 postinoculation days, neural disorders at 8 postinoculation days, 1 week earlier than those of the controls. Histopathological examination of both the treated and the control pigs revealed non-purulent polioencephalomyelitis consisting of neuronal degeneration, perivascular cuffing, meningeal infiltration, focal and diffuse gliosis. The severity of the histopathological lesions in the treated pigs was more prominent than those of the controls
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