Plasma levels and pharmacokinetics of cephaloridine after its repeated parenteral administration in buffalo calves (Bubalus bubalis)
1990
Chaudhary, K.R. | Srivastana, K.A. (Punjab Agricultural Univ., Ludhiana (India). College of Veterinary Science. Dept. of Pharmacology)
In the present investigation, plasma levels and pharmacokinetics of cephaloridine were investigated in buffalo calves following intramuscular administration (10 mg/kg) 6 h after its iv injection (10 mg/kg). The appreciable plasma concentration of 2.78+-0.28 ug ml-1 was recorded at 1 min and the peak plasma level (31.6+-1.50 ug ml-1) was measured at 30 min. The absorption half-life and elimination half-life were 0.037+-0.011 and 2.24+-0.30 h, respectively. In general the disposition behaviour of cephaloridine when given by repeated administration did not vary significantly from its single intramuscular dose.
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