Increased levels of progesterone in rats following acute ethanol treatment

Budec, M.; Trtic, T.; Balint-Peric, Lj.; Bugarski, D.

Increased levels of progesterone in rats following acute ethanol treatment

1996

Budec, M. (Institute for Medical Research, Belgrade (Yugoslavia)) | Trtic, T. | Balint-Peric, Lj. | Bugarski, D.

The purpose of this study was to investigate the effect of a single dose of ethanol on reproductive hormone production in female rats. Adult female Wistar rats were injected with alcohol (4g/kg) or equal volume of saline i.p. on diestrus day 1. The animals were sacrificed 1/2 h and 3 h after treatment. The results showed that acute ethanol treatment had no significant influence on LH and oestradiol levels, but significantly increased progesterone concentration. Since ethanol induced elevated levels of progesterone in male rats as well and caused a significant increase in the level of ACTH, the data obtained indicated that the increased progesterone concentration in female rats might be the result of activation of the adrenal glands.

Показать больше [+]