Studies of chloramphenicol effects on white blood cell count of rams
1996
Zecevic, S. (Veterinarski fakultet, Beograd (Yugoslavia)) | Zivanov, D. | Jovanovic, M. | Pejin, I. | Mirilovic, M. | Rusov, C.
Experiments were performed on 20 clinically healthy rams of the Tsigai breed, from 3 to 5 years of age and from 80 to 85 kg of body mass. Control rams received a daily dose of 5 ml of physiological solution, and experimental rams chloramphenicol in daily dose of 450 mg (0-1), 900 mg (0-2) or 1800 mg (0-3), during five days, intramuscularly. On the basis of the results the following can be concluded: 1) the therapeutic dose of chloramphenicol (900 mg) induces leucosis, and the double dose of this antibiotic (1800 mg) induces leucocytopenia; and 2) animal treated with chloramphenicol developed neutropenia, lymphocytosis and monocytosis, as well as transitional eosinophilia.
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