Complement-mediated inhibition of precipitation of immune complexes from serum domestic animals
1997
Rodic, B. (Zavod za transfuziju, Beograd (Yugoslavia)) | Lazarevic, M. | Saracevic, M. | Radojicic, C. | Popovic, O. | Miletic, V.
Results of investigations of the capability of the complement system of serums of horses, cows, sheep, goats, swine and dogs to prevent the precipitation of immune complexes in vitro were processed in this work. For testing this occurrence, the kinetic nephelometric procedure was used. For the formation of immune complexes in the test system, in an equivalent ratio, beef serum albumin and antibodies against it were used. The complement from the serum of all six tested animal species showed a strong inhibitory activity in the prevention of the depositing of immune complexes in the range of 81.03-93.88. The highest degree of inhibitory activity was determined in samples originating from goat, sheep and swine. By using the t-test, statistically significant differences were established in the comparison of the values obtained for the degree of inhibition of precipitation of immune complexes with serum complements between horses and sheep, horses and goats, horses and swine, sheep and dogs, goats and dogs, and swine and dogs.
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