Proliferative kinetics of human lymphocytes treated with cloprostenol in vitro

Djelic, N. . Faculty of Veterinary Medicine, Department of Biology

Proliferative kinetics of human lymphocytes treated with cloprostenol in vitro

1999

Djelic, N. (University of Belgrade, Belgrade (Yugoslavia). Faculty of Veterinary Medicine, Department of Biology)

Cloprostenol, a synthetic analogue of prostaglandin F2alfa is widely used in for oestrous synchronization in domestic animals. Previous investigations have revealed a certain genotoxic potential of PGF2alfa and cloprostenol on cultured human lymphocytes. The aim of this investigation was to evaluate the effects of cloprostenol on mitotic activity of human lymphocytes in vitro. Four experimental concentrations of cloprostenol (1, 2, 5 and 10 microgram/ml) were used. The results obtained indicate that cloprostenol did not change the percentage of cells in mitosis, or the proliferative kinetics of cultured human lymphocytes.

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