Stimulation of insulin secretion by amino acids in starry flounder, Platichthys stellatus
1998
Andoh, T. (Hokkaido National Fisheries Research Inst., Yoichi (Japan)) | Nagasawa, H.
Insulinotropic effects of several amino acids were compared by measuring of plasma total insulin levels after intramuscular injection of four kinds of amino acids in starry flounder (Platichthys stellatus). Total insulin levels in plasma were measured by the competitive enzyme immunoassay established previously for barfin flounder insulins. The results of amino acid administration experiments indicated that L-arginine and L-serine had strong insulinotropic effects. Weak insulinotropic effect was also observed in L-threonine, but the effect was much lower than those of L-arginine and L-serine. L-Histidine did not show any effect. This study is the first description about strong insulinotropic effect of L-serine in fish. Although plasma glucose levels increased after injected of every amino acids, there were no correlations between insulinotropic effects and average elevated plasma glucose levels among the four experimental groups. These results suggest that insulinotropic effects of L-arginine, L-serine and L-threonine administrations are independent of simultaneous increase of plasma glucose levels
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