Effect of transmural stimulation to motility on isolated gastric smooth muscle

Kim, J.H. . College of Veterinary Medicine and Institute of Animal Medicine; Shim, C.S. . Eastern Branch; Hong, Y.G.; Gyeongsang National University, Chinju . Department of Biochemistry, College of Natural Science

Effect of transmural stimulation to motility on isolated gastric smooth muscle

1999

Kim, J.H. (Gyeongsang National University, Chinju (Korea Republic). College of Veterinary Medicine and Institute of Animal Medicine) | Shim, C.S. (Gyeongnam Livestock Promotion institute, Chinju (Korea Republic). Eastern Branch) | Hong, Y.G. | Gyeongsang National University, Chinju (Korea Republic). Department of Biochemistry, College of Natural Science)

To elucidate the action of the cholinergic and adrenergic nerve on isolated gastric fundus smooth muscle of rabbit, the effects of electrical transmural stimulation were investigated in the presence of atropine, cholinergic receptor blocker; phentolamine, nonselective alpha-adrenergic receptor blocker; propranolol, nonselective beta-adrenergic receptor blocker and L-arginine from the isometric contraction of physiological recording system. 1. The contractile response induced by electrical transmural stimulation was increased as the frequency(1~32Hz)-dependent manner on the isolated gastric fundus smooth muscle. 2. The contractile response induced by electrical transmural stimulation was markedly inhibited by the pretreatment of atropine(1 microM). 3. The contractile response induced by electrical transmural stimulation was inhibited by the pretreatment of phentolamine(1 microM). 4. The relaxative response induced by electrical transmural stimulation on presence of atropine (1 microM) was inhibited by the pretreatment of propranolol(1 microM). 5. The relaxative responses on precontraction induced by histamine(10 microM) with guanethidine (50 microM) and atropine(1 microM) by electrical transmural stimulation were incresed by L-arginine(1mM). These fingings suggest that it was the exciatory action of cholinergic and alpha-adrenergic nerve, and the inhibitory action of beta-adrenergic nerve and nonadrenergic noncholinergic nerve on the isolated gastric fundus smooth muscle of rabbit.

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