Central serotonin modulates insulin secretory response to glucose
1998
Kurose, Y. (Kitasato Univ., Towada, Aomori (Japan). Coll. of Veterinary and Animal Sciences) | Wakata, Y. | Sakashita, Y. | Terashima, Y.
Serotonin is one of neurotransmitters existing in various sites of the brain. Central serotoninergic systems have been suggested to influence endocrine systems. The objective of this study is to clarify the correlation between the activity of central serotoninergic neurons and peripheral insulin responsiveness to glucose. Para-chlorophenylalanine (pCPA), a serotonin depletor, was used to inhibit serotonin synthesis in the brain. Insulin secretory response to glucose was evaluated by a hyperglycemic clamp experiment in pCPA-treated and saline-treated rats. The mean increment of serum insulin concentration (MSII) was significantly lower (P0.01) in pCPA-treated animals than in saline-treated controls in spite of no difference in glucose infusion rates (GIR) and blood glucose concentrations between the two groups. The MSII/GIR ratio, an index of insulin secretory response to glucose infusion, was significantly (P0.01) lower in pCPA-treated animal s than in saline-treated controls. The present study clearly demonstrates that serotonin deficiency in the brain, which attenuates serotoninergic activity, depresses insulin secretory response to glucose
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