Significance of different types and levels of antigen-specific immunity to Actinobacillus pleuropneumoniae infection in piglets
Nechvatalova, K.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))E-mail:[email protected] | Knotigova, P.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)) | Krejci, J.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)) | Faldyna, M.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)) | Gopfert, E.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)) | Satran, P.(Veterinarni a Farmaceuticka Univ., Brno (Czech Republic)) | Toman, M.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))
Twenty-eight piglets were used to test if a reliable protection against Actinobacillus pleuropneumoniae (App) infection can be obtained by colostrum-derived antibodies (CDA) and/or a low-dose infection from sows naturally infected with App. Piglets of groups 1A and 1B were the progeny of App-seronegative sows, piglets of groups 2A and 2B originated from App-seropositive sows. At the age of 4 weeks, piglets in groups 1A and 2A were exposed to a low infection dose with App serotype 9. At the age of 8 weeks, all four groups were exposed to the App serotype 9 challenge. Piglets that obtained CDA and experienced a low-dose App infection were best protected against App challenge. None of the types of protection prevented from developing the disease and characteristic changes in the lungs. Antibodies (IgG, IgA) present in the respiratory tract at the time of challenge played a major role in protection against App infection.
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