The role of central catecholaminergic systems in regulation of food intake of chicks
2001
Bungo, T. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture) | Ando, R. | Kawakami, S. | Ohgushi, A. | Furuse, M.
To clarify catecholaminergic systems on the regulation of food intake in the neonatal chick, we examined the effects of intracerebroventricular (ICV) injection of prazosin (alpha sub1-adrenoceptor antagonist), yohimbine (alpha sub2-adrenoceptor antagonist) and benserazide (an inhibitor of L-aromatic amino acid decarboxylase). We found that food intake was significantly suppressed by ICV injection of yohimbine (25 and 50micro g) over 60 min (P<0.05). Any doses ofprazosin (1.25, 2.5 and 5.0 micro g) did not alter food intake of chicks (P >0.05). ICV administration of benserazide induced a hypophagia after 60 min postinjection (P<0.05). It is suggested that catecholaminergic systems play an important role in the neural regulation of food intake in chicks, especially through alpha sub2-adrenoceptor.
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